Low frequency electromagnetic field decreases ischemia-reperfusion injury of human cardiomyocytes and supports their metabolic function

Experimental Biology and Medicine
Dariusz BiałyGrzegorz Sawicki

Abstract

Electromagnetic field at extremely low frequencies plays a significant role in the physiological function of human tissues and systems. It is shown that electromagnetic field inhibits production of reactive oxygen species which are involved in heart injury triggered by oxidative stress. We hypothesize that low frequency electromagnetic field protects function of cardiac cells from ischemia-reperfusion injury. Human cardiac myocytes, endothelial cells, and cardiac fibroblast underwent ischemia-reperfusion conditions in the presence or in the absence of low frequency electromagnetic field. LDH and MMP-2 activities (as markers of cell injury), and cell metabolic activity (by fluorescein diacetate staining) were measured to determine the protective role of low frequency electromagnetic field. Our data showed that short courses of low frequency electromagnetic field protect cardiac cells from cellular damage and preserve their metabolic activity during ischemia-reperfusion. This study demonstrates the possibility to use of low frequency electromagnetic field as strategy for the prevention or therapy of ischemia-reperfusion injury. Impact statement In our study, we showed that LF-EMF may be protective for heart during ischemia-reperf...Continue Reading

References

Jan 1, 1990·The Biochemical Journal·S TakahashiS M Factor
Oct 31, 1994·FEBS Letters·N M Hooper
Jan 1, 1996·Free Radical Biology & Medicine·H IshidaH Nakazawa
Nov 14, 1997·British Journal of Clinical Pharmacology·S R Maxwell, G Y Lip
Apr 20, 2002·Circulation Research·Yaara Ben-YosefAriel Miller
Jun 22, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Arthur A Pilla
Jul 8, 2003·The Journal of Pathology·Ivan Stamenkovic
Mar 23, 2005·Biochimie·Márton JaniLászló Patthy
May 2, 2006·Advances in Cardiology·Patrizia CamellitiPeter Kohl
Jan 26, 2008·Cell Death and Differentiation·T Klimova, N S Chandel
Jul 1, 2008·The International Journal of Biochemistry & Cell Biology·Stefano FaloneFernanda Amicarelli
Sep 27, 2008·Journal of Molecular and Cellular Cardiology·Mordechai ChevionEduard Berenshtein
Nov 28, 2008·Electromagnetic Biology and Medicine·Francesco RaggiRuggero Rossi
Jan 27, 2009·Progress in Histochemistry and Cytochemistry·Richard H W FunkNurdan Ozkucur
Feb 4, 2009·Antioxidants & Redox Signaling·David F Stowe, Amadou K S Camara
Jan 4, 2012·Journal of Cellular Physiology·Mohammad A M AliRichard Schulz
Jun 12, 2012·Trends in Cardiovascular Medicine·Mohammad A M AliRichard Schulz
Jul 11, 2013·Nature Reviews. Molecular Cell Biology·Mei XinRhonda Bassel-Duby
Apr 4, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yu ZhangZhonghua Liu

❮ Previous
Next ❯

Citations

Mar 3, 2020·Physiological Research·S CrucianiM Maioli
Nov 14, 2020·International Journal of Molecular Sciences·Marta BanaszkiewiczIwona Bil-Lula

❮ Previous
Next ❯

Methods Mentioned

BETA
Protein Assay

Software Mentioned

Viofor JPS
Quantity One

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.