Low-frequency flexural wave based microparticle manipulation.

Lab on a Chip
Hunter BachmanTony Jun Huang

Abstract

Manipulation of microparticles and bio-samples is a critical task in many research and clinical settings. Recently, acoustic based methods have garnered significant attention due to their relatively simple designs, and biocompatible and precise manipulation of small objects. Herein, we introduce a flexural wave based acoustofluidic manipulation platform that utilizes low-frequency (4-6 kHz) commercial buzzers to achieve dynamic particle concentration and translation in an open fluid well. The device has two primary modes of functionality, wherein particles can be concentrated in pressure nodes that are present on the bottom surface of the device, or particles can be trapped and manipulated in streaming vortices within the fluid domain; both of these functions result from flexural mode vibrations that travel from the transducers throughout the device. Throughout our research, we numerically and experimentally explored the wave patterns generated within the device, investigated the particle concentration phenomenon, and utilized a phase difference between the two transducers to achieve precision movement of fluid vortices and the entrapped particle clusters. With its simple, low-cost nature and open fluidic chamber design, this p...Continue Reading

References

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Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyun DingTony Jun Huang
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Aug 1, 2013·Lab on a Chip·Xiaoyun DingTony Jun Huang
Nov 20, 2015·Lab on a Chip·Jun ZhangWeihua Li
Jul 28, 2016·Science Advances·David J CollinsYe Ai
Jan 10, 2017·ACS Nano·Zhangming MaoTony Jun Huang
Jul 1, 2017·Advanced Functional Materials·Wujun ZhaoLeidong Mao
Jan 6, 2018·Lab on a Chip·Hunter BachmanTony Jun Huang
Jun 27, 2018·Lab on a Chip·Armaghan FakhfouriAdrian Neild
Jul 28, 2018·Nature Communications·Steven Peiran ZhangTony Jun Huang
Nov 28, 2018·Nature Methods·Adem OzcelikTony Jun Huang
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Asier Marzo, Bruce W Drinkwater
Dec 19, 2018·Analytical Chemistry·Peng Li, Tony Jun Huang
Jun 27, 2019·Lab on a Chip·Hunter BachmanTony Jun Huang
Nov 14, 2019·Lab on a Chip·Zeyu WangTony J Huang
Jan 10, 2020·Lab on a Chip·Ulri N LeeErwin Berthier

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Citations

Dec 24, 2020·Lab on a Chip·Amirreza AghakhaniMetin Sitti
Feb 25, 2021·Research : a Science Partner Journal·Ye YangHairong Zheng
Jul 17, 2021·Lab on a Chip·Kirill KolesnikDavid J Collins

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Matlab script
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