PMID: 3770122Nov 1, 1986Paper

Low-frequency kindling as a new experimental model of epilepsy

Experimental Neurology
Y MinabeI Nakamura

Abstract

Ten cats were stimulated twice a day in the lateral amygdala with low-frequency stimulation of about 3 Hz until generalized convulsion occurred. After the completion of kindling, the longest interpulse interval required for provocation of generalized convulsion (pulse-interval threshold) was determined in each subject. The pulse-interval threshold was 1300 ms in five cats, and 900 ms in five other cats. Then the stability of pulse-interval threshold and of the number of stimulating pulses required for provocation of afterdischarge when the stimulation was delivered with the pulse-interval threshold (pulse-number threshold) was tested. The pulse-interval threshold, pulse-number threshold, and duration of afterdischarge in each stimulation did not change statistically at the interstimulation interval from 24 h to 7 days. Phenobarbital and diphenylhydantoin elevated the pulse-number threshold significantly. We propose that low-frequency kindling is a valuable experimental model of epilepsy in assessing simply and precisely the susceptibility of the epileptic focus itself and the severity of epileptic seizures.

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Citations

Dec 29, 2000·Depression and Anxiety·E M Wassermann
May 1, 1989·Brain Research·Y MinabeM Kurachi
Aug 1, 1991·Brain Research. Molecular Brain Research·G C TeskeyD P Cain
Mar 1, 1993·Epilepsy Research·E W Lothman, J M Williamson
Sep 23, 2003·Brain Research. Brain Research Reviews·Alexander T Sack, David E J Linden
Jun 1, 1988·The Japanese Journal of Psychiatry and Neurology·Y MinabeM Kurachi
Jul 28, 2010·Epilepsia·Kara Buehrer KileDominique M Durand
Aug 20, 2021·Frontiers in Systems Neuroscience·Ping Chou, Chung-Chin Kuo

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