Low Frequency of IgE-Mediated Food Hypersensitivity in Mastocytosis.

The Journal of Allergy and Clinical Immunology. in Practice
Jesper JarkvistTheo Gülen

Abstract

Patients with mastocytosis have an increased risk for severe anaphylaxis, particularly to Hymenoptera venoms. These patients may also develop more often systemic hypersensitivity reactions to certain foods. However, this issue has not been systematically investigated. To determine prevalence and severity of food hypersensitivity (FH) reactions among patients with clonal mast cell disorders (CMDs). A retrospective study was conducted among 204 (age ≥18 years) consecutive patients who presented with confirmed CMD (170 with mastocytosis and 34 with monoclonal mast cell activation syndrome). All patients underwent thorough allergy workup where self-reported FH reactions were evaluated. The prevalence of self-reported FH was 20.6%. The frequency of immunologically mediated reactions was uncommon, because only 3.4% were confirmed by relevant history and IgE sensitization. Among patients with FH, 5 had severe anaphylaxis corresponding to an overall prevalence of 2.5%. Most symptoms were restricted to skin (86%), followed by gastrointestinal tract symptoms (45%)-similar to symptoms that occur in patients with mastocytosis also without food intake. Nuts, spicy foods, seafood, and alcohol were the most common incriminated elicitors. Ther...Continue Reading

Citations

Jan 26, 2021·American Journal of Clinical Dermatology·Julie V Schaffer
Feb 10, 2021·Current Allergy and Asthma Reports·Theo Gulen, Cem Akin
Feb 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Jeffrey G Demain, Melody C Carter
Feb 5, 2021·International Journal of Molecular Sciences·Jan RomantowskiPeter Valent
Apr 4, 2021·International Journal of Molecular Sciences·Knut BrockowPeter Valent
May 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Leander P De PuysseleyrVito Sabato
May 10, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Stephanie PulferAlexander Zink
Jun 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Theo GülenPeter Valent
Jul 23, 2021·Current Opinion in Allergy and Clinical Immunology·Vito SabatoJoana Vitte
Dec 7, 2021·Allergy and Asthma Proceedings·Alyssa G Burrows, Anne K Ellis

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