Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report

Acta neurochirurgica
Robert CornsMark Hill

Abstract

Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.

References

Jun 1, 1986·Journal of Clinical Pathology·K C GatterD Y Mason
Feb 1, 1993·Neurology·M P McCueE T Hedley-Whyte
Mar 1, 1996·Journal of Neuro-oncology·K KleopaH Reichmann
Mar 1, 1997·Acta Radiologica·H LanfermannK Lackner
Feb 5, 2000·Journal of Neurosurgery·B BatailleF Lapierre
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·N HayabuchiY Onizuka
Aug 29, 2001·Neurology·J M GijtenbeekL M DeAngelis
May 30, 2002·Neurology·A J M FerreriJ Y Blay
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tamara N ShenkierJoseph M Connors
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracy Batchelor, Jay S Loeffler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.