Low-grade Cribriform Cystadenocarcinoma: A Review of the Literature and Case Report

Plastic and Reconstructive Surgery. Global Open
Nao WakabayashiRei Ogawa

Abstract

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare tumor of the salivary gland that most often arises from the parotid gland. A 51-year-old man developed a small mass on the right parotid gland 5 years ago. A preoperative magnetic resonance image showed abnormal intensity, an atypical characteristic for such a tumor; therefore, the diagnosis was difficult. Thus, a superficial parotidectomy was performed as a total excisional biopsy to remove the tumor. Histopathological analyses revealed that the tumor was composed of a single cyst comprising cells containing mucosal fluid, with proliferation of large cells. Also, proliferation of the tumor epithelium showed a papillary cribriform pattern of proliferation with a partial ring form, and the tissue inside the tumor was replaced by a hematoma. Mild cellular atypia was observed. Immunostaining for S-100 was positive, and the Ki-67 ratio was <5%. These histopathological findings led to a diagnosis of LGCCC of the parotid gland. At 54 months after surgery, the patient has had no recurrence or facial palsy. LGCCC is a rare neoplasm of the salivary gland and is listed in the current World Health Organization classification (2005) as a variant of cystadenocarcinoma. This case sugg...Continue Reading

Citations

Aug 31, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Andrea PalicelliGuido Valente
Nov 8, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Andrea Palicelli
Aug 10, 2019·Diagnostic Cytopathology·Siba El Hussein, Samer N Khader
Nov 22, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Andrea Palicelli
Jan 28, 2021·Head and Neck Pathology·Daniela RussoFrancesco Merolla

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