PMID: 8972766Nov 1, 1996Paper

Low-grade fibromyxoid sarcoma

Virchows Archiv : an International Journal of Pathology
M FukunagaN Fukunaga

Abstract

A low-grade fibromyxoid sarcoma arising in the thigh of a 16-year-old Japanese girl is described. The patient had a well-circumscribed mass measuring 3.5 cm in its greatest diameter within her left vastus medialis muscle and a 6-month history of pain. Microscopically, the tumour was not encapsulated and filtrated into adjacent skeletal muscle. The tumour was characterized by poor to moderate cellularity, a proliferation of bland-appearing spindle tumour cells, and alternating fibrous and myxoid areas with a whorled pattern of the tumour cells. Neither cellular atypia nor mitotic figures were observed. There was no tumour necrosis. Immunohistochemically, the tumour cells were diffusely and strongly positive for vimentin and desmin. Some cells contained alpha smooth muscle actin. They were uniformly negative for CAM5.2, epithelial membrane antigen, muscle-specific actin (HHF35), factor-VIII-related antigen, S-100 protein, neurofilament, CD34, and CD31. The tumour had a diploid DNA content with S-phase fractions of 6.6% by flow cytometry. The patient was alive with no evidence of disease 11 months after excision.

Citations

Apr 9, 2010·Musculoskeletal Surgery·Angela NotarnicolaBiagio Moretti
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Manju L PrasadRichard T Kloos
Nov 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mauro PapottiJuan Rosai
Sep 1, 1999·Histopathology·K Y HoC M Tang
Mar 21, 2002·Expert Review of Molecular Diagnostics·G RindiA Scarpa
Dec 2, 2011·Hand : Official Journal of the American Association for Hand Surgery·Guy RubinNimrod Rozen
Dec 9, 2003·The Kaohsiung Journal of Medical Sciences·Sheau-Fang YangChien-Kao Wang
Jan 11, 2011·Gastroenterología y hepatología·Goizalde Solano IturriVictor Orive Cura
Mar 24, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zhen TangXiao-gang Xu
Nov 6, 2013·Journal of Cutaneous Pathology·Michael P SedrakJerad M Gardner
Nov 26, 2013·Histopathology·Andrew L Folpe
Jul 31, 2010·Journal of Orthopaedic Surgery and Research·Christina ArnaoutoglouTheodoros A Xenakis
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·I TakanamiM Naruke

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