Low-grade systemic inflammation and suboptimal bone mineral density throughout adolescence: a prospective study in girls

Clinical Endocrinology
Raquel LucasHenrique Barros

Abstract

We aimed at quantifying the associations between high-sensitivity C-reactive protein (hs-CRP) and forearm bone mineral density (BMD) throughout adolescence in overweight and normal-weight girls. Prospective cohort study. 346 girls born in 1990 and attending schools in Porto, Portugal. Adolescents were evaluated at 13 and 17 years of age using a standard protocol. Forearm BMD was measured by dual-energy X-ray absorptiometry. Anthropometric assessment included weight, height, body fat percentage and waist circumference. Girls were categorized according to age- and sex-specific body mass index (BMI) percentiles as normal weight in both evaluations or overweight in at least one assessment. Pubertal development was estimated using menarche age. Serum hs-CRP was determined using particle-enhanced immunonephelometry. Hs-CRP was log-transformed, and associations were quantified using linear regression coefficients and 95% confidence intervals (95%CI). An inverse association between hs-CRP and BMD was observed from 13 years of age in overweight girls [-11·26 mg/cm(2) (-21·99, -0·52)]. Among normal-weight adolescents, 13-year-old hs-CRP was negatively associated with prospective BMD variation between 13 and 17 years of age [-1·90 mg/cm(2...Continue Reading

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Citations

Mar 13, 2014·Archives of Osteoporosis·Sara LourençoHenrique Barros
Mar 9, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J van LeeuwenM van Middelkoop
Jun 24, 2017·PloS One·Heli T ViljakainenOuti Mäkitie
Aug 17, 2018·Diabetes Research and Clinical Practice·Namrata SanjeeviTonja R Nansel

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