Low-grade, systemic inflammation in adolescents: association with early-life factors, gender, and lifestyle

American Journal of Epidemiology
Jatta PirkolaAnneli Pouta

Abstract

Low-grade, systemic inflammation is related to increased risk of cardiovascular disease in adults. The proinflammatory state tracks from adolescence to adulthood. Identifying correlates of inflammation in adolescents could provide opportunities to prevent cardiovascular disease in adulthood. However, population-based data on correlates of inflammation in adolescence are limited. Therefore, the authors studied the associations of early-life factors, gender, and lifestyle with inflammation (measured by high-sensitivity C-reactive protein and leukocyte count) at age 16 years (2001-2002) in the prospective, population-based Northern Finland Birth Cohort 1986 Study (n = 5,240). In females, being born small for gestational age and current use of oral contraceptives were associated with the proinflammatory state. The association of birth size with inflammation was not observed in males. In logistic regression analyses, oral contraceptive use (odds ratio (OR) = 2.83), abdominal obesity (OR = 5.17), and smoking (OR = 2.72) were associated with elevation of both inflammation markers in females; abdominal obesity (OR = 5.72) and smoking (OR = 2.02) were associated in males. Thus, females appear more susceptible to the adverse effects of b...Continue Reading

References

Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·M R JärvelinP Rantakallio
Apr 13, 2000·American Journal of Clinical Pathology·E Grimaldi, F Scopacasa
Nov 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·M VääräsmäkiA L Hartikainen
Aug 13, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Mikko J JärvisaloOlli T Raitakari
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Jane E RamsayNaveed Sattar
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Naveed SattarGraham Watt
Jun 24, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M J A WilliamsR Poulton
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Oct 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·P HedbergM Puukka
Apr 2, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Arthur W ZieskeUNKNOWN Pathobiological Determinants of Atherosclerosis in Youth Research Group
Jan 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H D McCarthy, M Ashwell
May 27, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Markus JuonalaOlli T Raitakari
Sep 9, 2006·The American Journal of Clinical Nutrition·Julia WärnbergUNKNOWN AVENA Study Group
Mar 6, 2007·Preventive Medicine·Marko T KantomaaAnja M Taanila
Jun 29, 2007·Medicine and Science in Sports and Exercise·Tuija TammelinSimo Näyhä
Dec 7, 2007·International Journal of Epidemiology·Rüdiger von KriesUNKNOWN GME Study Group
Feb 19, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E OkenM W Gillman
Feb 26, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Betty R Vohr, Charlotte M Boney
Mar 8, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer O'LoughlinGilles Paradis
Apr 10, 2008·The British Journal of Nutrition·Paul TrayhurnI Stuart Wood
Jun 14, 2008·Diabetes/metabolism Research and Reviews·Marie L S LindegaardLars B Nielsen
Feb 26, 2009·Sleep·Sanjay R PatelSusan Redline
Mar 20, 2009·The American Journal of Clinical Nutrition·Amélie CartierJean-Pierre Després

❮ Previous
Next ❯

Citations

Feb 18, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Carolina CaminitiCarmen S Mazza
May 27, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stefan KluzekJulia Newton
Dec 20, 2015·Sleep Medicine Reviews·Jonas S QuistMads F Hjorth
Apr 23, 2016·Diabetes Research and Clinical Practice·Louise KelstrupPeter Damm
Nov 1, 2011·Sleep Medicine·David Martinez-GomezUNKNOWN AFINOS Study Group
Nov 18, 2015·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Pedro Paulo do Prado JuniorSilvia Eloiza Priore
Aug 16, 2011·The Journal of Pediatrics·David Martinez-GomezUNKNOWN AFINOS Study Group
May 18, 2011·American Journal of Obstetrics and Gynecology·Gesina D S ErnstVincent W V Jaddoe
Apr 14, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Lorin Lakasing, Catherine Williamson
May 3, 2013·Clinical Psychological Science : a Journal of the Association for Psychological Science·Michael L M MurphyGregory E Miller
Jan 21, 2011·The Journal of Nutrition·Caroline M P VérierUNKNOWN HELENA study group
Aug 30, 2017·Acta Cardiologica·Michael V FedewaEllen M Evans
Aug 1, 2018·Journal of Addiction Medicine·Bhavita KumariKashif Shafique
Jun 12, 2020·Frontiers in Physiology·Brianna LarsenClare Minahan
May 31, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L M CoheleyR D Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.