Low Hemoglobin A1c Increases the Risk of Disability in Community-dwelling Older Non-diabetics Adults

The Journal of Nutrition, Health & Aging
K-I KimH J Chin

Abstract

To describe the health characteristics of individuals with low HbA1c levels and evaluate the association between HbA1c level and disability or all-cause mortality in non-diabetic older adults. Prospective observational cohort study. Seongnam, Gyeongi Province, Korea. Among the 1,000 community-dwelling Koreans ≥ 65 years of age who were followed for 5 years, 760 non-diabetic individuals were analyzed. Activities of Daily Living (ADL) and Instrumental ADL (IADL) were evaluated and mortality data were obtained from the National Statistics Office of Korea. The mean age was 76.3 (SD 9.0) years, and 319 subjects (42.0%) were male. Lower level of HbA1c was associated with less frequent hypertension and less frequent use of aspirin or statin, and lower values of body mass index, hematocrit, total iron-binding capacity, albumin, and cholesterol level. The participants were categorized into 3 groups according to their HbA1c (group I, < 5.5%; group II, 5.5~5.9%; and group III, 6.0 ~ 6.4%). Although, there was no significant difference in functional status according to baseline HbA1c level, disability was more frequently observed as the HbA1c level decrease (18.3% in group I, 12.5% in group II, and 5.3% in group III, p=0.029) at the 5-year...Continue Reading

References

Apr 29, 1998·JAMA : the Journal of the American Medical Association·S K InouyeJ Concato
Aug 26, 1998·Journal of the American Geriatrics Society·S ShiloM Sonnenblick
Jun 21, 2005·Journal of the American College of Cardiology·Diane L LucasThomas D Giles
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Rachel A WhitmerJoseph V Selby
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Oct 7, 2010·Circulation. Cardiovascular Quality and Outcomes·April P CarsonPaul Muntner
Apr 5, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C Barrett BowlingRichard M Allman
Oct 25, 2011·The American Journal of Medicine·Laura BoucaiJoel Zonszein
Aug 3, 2012·Diabetes Care·Vikas AggarwalElizabeth Selvin
Mar 29, 2014·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
May 21, 2014·Journal of Diabetes Investigation·Ji Cheol BaeKwang-Won Kim
Jun 9, 2014·Age and Ageing·Ho Jun ChinKwang-Il Kim

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Citations

Jul 21, 2017·NPJ Parkinson's Disease·James Freed, Lisa Chakrabarti
Jun 3, 2021·International Journal of Molecular Sciences·Marc-Olivier DeguiseRashmi Kothary

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