Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency

PloS One
Femkje A M JonkerMichael Boele van Hensbroek

Abstract

A reliable diagnostic biomarker of iron status is required for severely anemic children living in malarious areas because presumptive treatment with iron may increase their infection risk if they are not iron deficient. Current biomarkers are limited because they are altered by host inflammation. In this study hepcidin concentrations were assessed in severely anemic children living in a highly malarious area of Malawi and evaluated against bone marrow iron in order to determine the usefulness of hepcidin as a point of care test. 207 severely anemic children were assessed for levels of hepcidin, ferritin, serum transferrin receptor, erythropoietin, hematological indices, C-reactive protein, interleukin-6, malaria parasites and HIV infection. Deficiency of bone marrow iron stores was graded and erythroblast iron incorporation estimated. Interaction of covariates was assessed by structural-equation-modeling. Hepcidin was a poor predictor of bone marrow iron deficiency (sensitivity 66.7%; specificity 48.5%), and of iron incorporation (sensitivity 54.2%; specificity 61.8%), and therefore would have limitations as a point of care test in this category of children. As upregulation of hepcidin by inflammation and iron status was blunte...Continue Reading

References

Jun 24, 1982·The New England Journal of Medicine·C A Finch, H Huebers
Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·G NicolasS Vaulont
Sep 5, 2001·Journal of Clinical Pathology·B J Bain
Jul 1, 1963·The Journal of Clinical Investigation·E GALET BOTHWELL
Sep 29, 2004·Journal of Clinical Pathology·D A HughesB J Bain
Feb 29, 2008·The New England Journal of Medicine·Job C J CalisMichaël Boele van Hensbroek
May 24, 2008·The New England Journal of Medicine·Stephen M Graham
Jul 7, 2010·Cell·Matthias W HentzeClara Camaschella
Aug 27, 2010·Clinical Chemistry·Joyce J C KrootDorine W Swinkels
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilio RamosTomas Ganz
May 17, 2011·Nature Medicine·Silvia PortugalMaria M Mota
Oct 13, 2011·Clinical Chemistry·Joyce J C KrootDorine W Swinkels
Jan 27, 2012·The New England Journal of Medicine·Robert E Fleming, Prem Ponka
Aug 24, 2012·PloS One·Femkje A M JonkerTjalling Leenstra

❮ Previous
Next ❯

Citations

Apr 17, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lieke UijterschoutFrank Brus
Dec 3, 2015·EBioMedicine·Sarah H AtkinsonThomas N Williams
Aug 1, 2014·Frontiers in Pharmacology·Manfred NairzGünter Weiss
Jun 10, 2014·Frontiers in Pharmacology·Natasha SpottiswoodeHal Drakesmith
May 6, 2016·Annual Review of Nutrition·Sant-Rayn PasrichaHal Drakesmith
Apr 12, 2017·British Journal of Haematology·Femkje A M JonkerMichael Boele van Hensbroek
Feb 15, 2018·Nutrients·Raúl DomínguezAlberto Pérez-López
Oct 20, 2018·Journal of Pediatric Hematology/oncology·Pooja DewanRajeev K Malhotra
Apr 6, 2016·Blood·Domenico GirelliDorine W Swinkels
Dec 11, 2014·Clinical Chemistry·Tomas Ganz
May 31, 2018·Blood Advances·Trygve S EllingsenJohn-Bjarne Hansen
Sep 26, 2020·International Journal of Molecular Sciences·Kelvin M AbugaSarah H Atkinson
Apr 15, 2017·European Journal of Applied Physiology·Peter PeelingLouise M Burke
May 25, 2021·The Cochrane Database of Systematic Reviews·Maria Nieves Garcia-CasalJuan Pablo Peña-Rosas

❮ Previous
Next ❯

Methods Mentioned

BETA
bone marrow aspiration

Software Mentioned

AMOS
SPSS

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Advances in Nutrition
Natasha SpottiswoodePatrick E Duffy
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Khumbo KaluaP Courtright
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
F M SalaniponiM W Borgdorff
© 2021 Meta ULC. All rights reserved