Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity

Proceedings of the National Academy of Sciences of the United States of America
A HellstromL E Smith

Abstract

Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel development. In vitro, low levels of IGF-I prevent vascular endothelial growth factor-induced activation of protein kinase B (Akt), a kinase critical for endothelial cell survival. Our results from studies in premature infants suggest that if the IGF-I level is sufficient after birth, normal vessel development occurs and retinopathy of prematurity does not develop. When IGF-I is persistently low, vessels cease to grow, maturing avascular retina becomes hypoxic and vascular endothelial growth factor accumulates in the vitreous. As IGF-I increases to a critical level, retinal neovascularization is triggered. These data indicate that serum IGF-I levels in premature infants can predict which infants will develop retinopathy of prematurity and further suggests that early restoration of IGF-I in premature infants to normal levels could prevent this disease.

References

Feb 1, 1977·Archives of Ophthalmology·J T FlynnW Milam
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·A BennettR L Hintz
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Jan 15, 1996·The Journal of Clinical Investigation·B M JohnstonP D Gluckman
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·G S RobinsonL E Smith
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·W J SmithD R Clemmons
May 27, 1999·International Ophthalmology Clinics·B D Simons, J T Flynn
Sep 2, 1999·Current Biology : CB·B J MichellR B Pearson
Mar 10, 2000·International Ophthalmology Clinics·J C MorrisonE C Johnson
Jun 28, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J SprangerA F Pfeiffer

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Citations

Jun 8, 2004·Archives of Pharmacal Research·Yong Hee Lee, Morris F White
Dec 3, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M Heckmann
Aug 20, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A StahlW Lagrèze
Jan 15, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Philip MaierHansjürgen T Agostini
May 23, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Birgit LorenzNico Schneider
Apr 2, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Se Joon WooKyu Hyung Park
Dec 3, 2011·Lasers in Medical Science·Samuel K HoustonTimothy G Murray
Oct 13, 2009·Journal of the Association for Research in Otolaryngology : JARO·María Eugenia Gómez-CasatiGabriel Corfas
Mar 3, 2007·Angiogenesis·Jing Chen, Lois E H Smith
Jun 10, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Bruce A Berkowitz, Robin Roberts
Sep 19, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Erica L FletcherJennifer L Wilkinson-Berka
Nov 3, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Elsa Kermorvant-DucheminSylvain Chemtob
Nov 6, 2010·Archives of Pharmacal Research·Dong Hyun JoJeong Hun Kim
Mar 14, 2012·Indian Pediatrics·H S NiranjanM Vasudeva Kamath
Apr 15, 2004·Immunology Letters·Thomas Wossning, Michael Reth
Oct 25, 2003·Progress in Retinal and Eye Research·Arup Das, Paul G McGuire
Feb 23, 2013·Seminars in Fetal & Neonatal Medicine·Anna-Lena HårdAnn Hellström
May 10, 2002·The American Journal of Pathology·James T Rosenbaum
Aug 9, 2003·Experimental Eye Research·Suzanne Claxton, Marcus Fruttiger
Mar 6, 2004·Seminars in Neonatology : SN·Lois E H Smith
Feb 25, 2003·Progress in Retinal and Eye Research·A N WitmerR O Schlingemann
Aug 1, 2011·Journal of Developmental Origins of Health and Disease·U SchubertM Norman
Sep 3, 2002·Nature Medicine·Lois E H Smith
Mar 16, 2013·Nature Reviews. Drug Discovery·Guillaume VaquerBruno Sepodes
May 28, 2002·Journal of Endocrinological Investigation·R Deghenghi
Mar 13, 2003·Kidney International·Gabriella GrudenGiancarlo Viberti
Apr 21, 2004·Retina·Franco M Recchia, Antonio Capone
Feb 12, 2009·Retina·Hugo Quiroz-MercadoRobinson Vernon Paul Chan
Dec 15, 2010·Current Opinion in Pediatrics·Jing ChenLois E Smith
Jul 3, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Brian William Fleck
Jan 25, 2005·The British Journal of Ophthalmology·W V Good, R L Gendron
Nov 21, 2007·The British Journal of Ophthalmology·Gerd HolmströmKeryn A Williams
May 30, 2002·The British Journal of Ophthalmology·C M WheatleyM M Sale
Oct 28, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Margaret A SchwarzHaihua Zheng
Nov 6, 2012·Oxidative Medicine and Cellular Longevity·Suk-Yee LiAmy C Y Lo
Oct 8, 2005·Biology of the Neonate·Lois E H Smith
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Kurt R Stenmark, Sarah A Gebb
Sep 3, 2010·The Journal of Clinical Investigation·Przemyslaw SapiehaSylvain Chemtob

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