Low immunogenicity in non-small cell lung cancer; do new developments and novel treatments have a role?

Cancer Metastasis Reviews
R E GardinerJohn Hinchion

Abstract

Approximately 1.6 million new cases of lung cancer are diagnosed annually (Jemal et al. CA: A Cancer Journal for Clinicians, 61, 69-90, 2011) and it remains the leading cause of cancer-related mortality worldwide. Despite decades of bench and clinical research to attempt to improve outcome for locally advanced, good performance status patients, the 5-year survival remains less than 15 % (Molina et al. 2008). Immune checkpoint inhibitor (ICH) therapies have shown a significant promise in preclinical and clinical trails to date in the treatment of non-small cell lung cancer (NSCLC). The idea of combining these systemic immune therapies with local ablative techniques is one that is gaining momentum. Electrochemotherapy (ECT) is a unique atraumatic local therapy that has had very promising objective response rates and a number of advantages including but not limited to its immunostimulatory effects. ECT in combination with ICHs offers a novel approach for dealing with this difficult disease process.

References

Jan 11, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M MirC Paoletti
Jan 1, 1995·The Journal of Clinical Endocrinology and Metabolism·T YanagawaL J DeGroot
Feb 1, 1995·American Journal of Clinical Oncology·J H SchillerM L Levitt
Jul 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D H JohnsonR F De Vore
Jul 17, 1999·Journal of Neuroimmunology·A LigersO Olerup
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SersaD J Chaplin
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G WideraJ B Ulmer
Jul 27, 2000·Seminars in Immunology·R E Langman, M Cohn
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Jun 11, 2003·Nature Immunology·Norihiko WatanabeKenneth M Murphy
Jun 24, 2003·Immunity·Gabriel L SicaLieping Chen
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Jul 9, 2003·The Journal of Experimental Medicine·Mohammed Javeed I AnsariMohamed H Sayegh
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Jul 29, 2004·JAMA : the Journal of the American Medical Association·Catherine DelbaldoJean-Pierre Pignon
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KonishiMasaharu Nishimura
Dec 2, 2004·Nature Reviews. Immunology·Dmitry Gabrilovich
Aug 9, 2005·The Journal of Surgical Research·Mehrdad NikfarjamChristopher Christophi
Nov 25, 2005·The Annals of Thoracic Surgery·Alex G LittleAndrew K Stewart
Feb 17, 2006·International Journal of Cancer. Journal International Du Cancer·Christian BlankAndreas Mackensen
Mar 23, 2006·Annual Review of Immunology·Wendy A TeftJoaquín Madrenas
May 12, 2006·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Tom Mala
May 26, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marcello Carlo AmbrogiAlfredo Mussi
Sep 16, 2006·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thomas Pradeu, Edgardo D Carosella
Mar 30, 2007·Radiology·Caroline J SimonWilliam W Mayo-Smith
Apr 17, 2007·Annals of Surgery·John O LarkinGerald C O'Sullivan
May 4, 2007·The Journal of Clinical Investigation·Jeremy B Swann, Mark J Smyth
Jul 7, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G SersaM Snoj
Dec 12, 2007·Techniques in Vascular and Interventional Radiology·Ryan A McTaggart, Damian E Dupuy

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Citations

Jul 11, 2018·Future Oncology·Francesco PassigliaRaffaele Conca
Dec 13, 2019·Immunotherapy·Elena GarelliStefan Andreas
Dec 4, 2019·Bioscience, Biotechnology, and Biochemistry·Xiaoming MaoHua Zhou
Jun 20, 2020·Respiratory Medicine Case Reports·Liliana Fernández-TrujilloLuz F Sua

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