Low incidence and severity of transplant-associated coronary artery disease in heart transplants from live donors

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Ani C AnyanwuMagdi H Yacoub

Abstract

Hearts transplanted from patients undergoing heart-lung transplantation (domino hearts) are unique because they have not been subjected to the deleterious effects of brain-stem death. This study examines the incidence and severity of transplant-associated coronary artery disease in recipients of domino hearts. We retrospectively reviewed angiographic and clinical data from 97 patients who survived more than 1 year after domino heart transplantation at our hospital. Duration of follow-up ranged from 1 to 11 years after transplantation. The diagnosis of coronary artery disease was based on angiographic criteria. At 1 year, freedom from angiographic coronary artery disease was 99% (70% confidence interval [CI], 97-100), at 5 years it was 83% (70% CI, 78-89), and at 10 years it was 77% (70% CI, 70-84). Donor age, cystic fibrosis in the donor, organ ischemia time during transplantation, and acute rejection after transplantation did not influence risk for the disease. We found an increased incidence of coronary disease in hearts from male donors compared with those from female donors: freedom from disease at 5 years was 72% (70% CI, 63-81) in men vs 93% (87-99) in women. Thirteen patients experienced coronary artery disease at a medi...Continue Reading

References

Jan 1, 1979·The Journal of Pediatrics·T J MossA J Moss
Jun 2, 1989·JAMA : the Journal of the American Medical Association·W A BaumgartnerB A Reitz
Apr 1, 1995·American Heart Journal·Hector O VenturaD D Stapleton
Oct 10, 1997·Circulation·M Weis, W von Scheidt
Dec 10, 1999·Transplantation·J Parameshwar
Feb 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M M BoucekJ D Hosenpud
Aug 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J D HosenpudR J Novick
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Johann PratschkeN L Tilney
Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ani C AnyanwuMagdi H Yacoub

Citations

Jun 12, 2012·Pediatric Cardiology·Don HayesT M Hoffman
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Jonah OdimDavid Gjertson
Oct 10, 2009·Circulation Research·Carl AtkinsonStephen Tomlinson
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Matthew J WeissJames S Allan
Mar 31, 2012·Transplantation Reviews·Bernhard FloerchingerStefan G Tullius
Apr 30, 2005·Congestive Heart Failure·Radha GoelMandeep R Mehra
Aug 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T L AstorT M Hoffman
Jan 18, 2005·The Journal of Surgical Research·Christian A SkrabalMatthias Loebe
Dec 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Emma J BirksAsghar Khaghani
Sep 24, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Asghar KhaghaniNicholas R Banner
Mar 5, 2004·Journal of the American College of Cardiology·Mandeep R MehraMyung H Park
Aug 2, 2011·Immunology Letters·Valeria CrudeleClaudio Napoli
Feb 22, 2017·Journal of Cardiac Surgery·Yasuhiro ShudoYiping Joseph Woo
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Friedhelm Beyersdorf
Dec 20, 2007·Transplantation Proceedings·O CohenH Laks
Oct 14, 2004·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Johann PratschkePeter Neuhaus
Sep 13, 2014·Journal of Tropical Pediatrics·Bandar A AlbaradiHadi S Al-Qahtani
Oct 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl AtkinsonStephen Tomlinson
Apr 18, 2006·Perfusion·Sana UllahMichael L Schmitz

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Heyman LuckrazStephen R Large
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Ani C AnyanwuMagdi H Yacoub
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Asghar KhaghaniNicholas R Banner
© 2021 Meta ULC. All rights reserved