PMID: 6109802Jan 17, 1981Paper

Low incidence of chlorpropamide-alcohol flushing in diet-treated, non-insulin-dependent diabetes

Lancet
N E deSilvaK G Alberti

Abstract

50 diet-treated, non-insulin-dependent diabetics were tested subjectively and objectively for chlorpropamide-alcohol flushing (CPAF) with a single challenge test. Of the 12 (24%) who reported a subjective flush, 9 (18%) also flushed when a placebo was given instead of chlorpropamide, so the true incidence of chlorpropamide-alcohol flushing was 4% (1 patient was not retested with placebo). In a control group of 21 non-diabetics, 2 showed the specific CPAF phenomenon. Temperature measurement did not improve discrimination, but it did show a faster rise in facial temperature in CPAF-positive subjects than in alcohol flushers. This study does not confirm previous higher estimates of the incidence of the CPAF phenomenon in non-insulin-dependent diabetes.

References

May 12, 1979·Lancet·R D LeslieD A Pyke
Jul 1, 1977·Clinics in Endocrinology and Metabolism·D A Pyke
Dec 2, 1978·British Medical Journal·R D Leslie, D A Pyke
Jul 26, 1980·British Medical Journal·A H Barnett, D A Pyke

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Citations

Sep 1, 1996·Diabetologia·Y SuzukiK Matsuoka
Jan 1, 1984·European Journal of Clinical Pharmacology·L GroopA Melander
Jan 1, 1983·European Journal of Clinical Pharmacology·P JerntorpA Melander
Oct 10, 1981·British Medical Journal·S MedbakL H Rees
Oct 10, 1981·British Medical Journal·A H BarnettM D Rawlins
Jan 28, 1984·British Medical Journal·P G WilesD A Pyke
Sep 5, 1987·British Medical Journal·M I FrazerE F Holland
Apr 1, 1983·Journal of Clinical Pathology·V Marks
Aug 20, 2004·Alcoholism, Clinical and Experimental Research·Yoshihiko SuzukiKempei Matsuoka
Apr 26, 2006·The Journal of School Health·Ximena Urrutia-Rojas, John Menchaca
Jan 1, 1984·Acta Medica Scandinavica·L GroopE M Tolppanen
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R W Stout

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