PMID: 9645413Jun 30, 1998Paper

Low incidence of osteoporosis in a two year follow-up of early community based patients with rheumatoid arthritis

Scandinavian Journal of Rheumatology
S AmanJ Risteli

Abstract

52 patients with early rheumatoid arthritis (RA) were followed with regular measurements of bone mineral density (BMD) and serum markers of type I collagen metabolism in order to determine whether they develop osteoporosis during the first two years of the disease course and if the changes in type I collagen metabolites reflect the alterations in BMD. The mean percentage BMD change over the first year of follow-up was -0.91 for lumbar spine (LS) and -0.76 for femoral neck (FN); the corresponding figures from 0 to 24 months was -1.3 and -0.8, respectively. During the follow-up, only five patients developed osteoporosis by the Z-score definition (<-1). If defined by T-score (<-2.5) none of the patients developed osteoporosis. The BMD change correlated neither with the clinical parameters of disease activity nor with the markers of collagen metabolism. However, the BMD change in FN was associated with the cumulative corticosteroid dose (r=-0.31, p <0.05, 95% CI -0.54 to -0.04). Reasons for the lack of accelerated bone loss in our series are open to various interpretations. This series was community based and most of the patients had mild RA. The patients were also actively treated and their physical function did not deteriorate.

References

Jul 1, 1989·Annals of the Rheumatic Diseases·P N SambrookM G Yeates
Sep 1, 1985·Annals of the Rheumatic Diseases·P N SambrookJ Reeve
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C HassagerC Christiansen
Jun 1, 1994·British Journal of Rheumatology·B D ShenstoneA K Bhalla

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Citations

Oct 2, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Harri HämäläinenAntero Kotaniemi
Oct 2, 2001·Scandinavian Journal of Rheumatology·C KellerUNKNOWN BARFOT study group
Dec 21, 2000·Current Rheumatology Reports·P BoulosJ D Adachi
Aug 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J D Adachi, A Papaioannou

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