Low incidence of red cell and HLA antibody formation by bone marrow transplant patients

Transfusion
A A Abou-ElellaC D Hillyer

Abstract

Bone marrow transplant (BMT) patients, although immunosuppressed, are at risk for the development of red cell (RBC) and HLA antibodies, and they often are given filtered blood in an effort to prevent the latter complication. This study attempts to determine the rate of formation and the specificity of both RBC and HLA alloantibodies in this patient population. BMT patients (148 received autologous marrow; 45 received allogeneic marrow) from an 18-month period, including patients with leukemia (57 patients), lymphoma (54), breast cancer (68), myeloma (8), myelodysplastic syndrome (5), and aplastic anemia (1), were studied to determine the rate of alloantibody formation to RBC and HLA antigens. A total of 2,410 RBC antibody screens were performed. The patients received 3,921 packed RBCs and 5,915 single-donor platelet units; all were irradiated and administered via white cell-reduction filters. Seven (3.6%) of 193 patients had RBC antibodies upon hospital admission. Four (2.1%) of 193 developed RBC antibodies during the course of BMT: 3 patients had one RBC antibody and 1 patient had two RBC antibodies. RBC antibodies included anti-E (n = 2), anti-M (n = 1), anti-Jkb (n = 1), and anti-Lu14 (n = 1). Thus, 98 percent of patients (1...Continue Reading

Citations

Sep 8, 2011·Bone Marrow Transplantation·S D RowleyP Bhattacharyya
Dec 10, 2013·Bone Marrow Transplantation·G S BoothB N Savani
Apr 22, 2008·Transfusion·Jose R Gonzalez-PorrasMercedes Corral
Jul 7, 2011·Vox Sanguinis·S ZalpuriJ G van der Bom
Dec 12, 2012·Tissue Antigens·A BrandD L Roelen
Aug 21, 2002·Hematology·G GandiniG Aprili
Jul 26, 2005·Seminars in Hematology·Lawrence D Petz
Mar 31, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Supriya Dhar, Sabita Basu
Apr 11, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Garrett S BoothBipin N Savani
Jul 22, 2016·Transfusion Medicine Reviews·Jennifer Webb, Allistair Abraham
Apr 23, 2016·American Journal of Hematology·Joep W R SinsKarin Fijnvandraat
Dec 17, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Claudia S Cohn

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The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.