Low insulin-like growth factor I and leukopenia in anorexia nervosa

The International Journal of Eating Disorders
Nicoletta PolliFrancesco Cavagnini

Abstract

Considering that leukopenia and anemia are commonly observed in anorexia nervosa (AN) and that growth hormone (GH) and insulin-like growth factor-I (IGF-I) markedly influence the activation, growth and survival of hemopoietic cells, we sought for possible relationships between hematologic parameters and the GH-IGF-I axis in a group of patients with AN. Twenty patients were studied. Leukocyte and erythrocyte counts, as well as baseline serum GH levels and IGF-I standard deviation score (SDS) values, were determined in each participant and correlations between parameters were searched. Leukocyte and erythrocyte counts, as well as IGF-I SDS values, were significantly lower, conversely GH was significantly higher in AN patients than in normal weight participants. In patients, IGF-I SDS values were positively correlated with leukocyte count and BMI, whereas no correlation was found between IGF-I SDS and hemoglobin or erythrocytes. The demonstration of a positive correlation between leukocyte number and circulating IGF-I in AN suggests a likely pathogenetic role of IGF-I deficiency in this hematologic abnormality.

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Citations

Nov 26, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andrea TrombettiRené Rizzoli
Jun 6, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Fotios C PapadopoulosAnders Ekbom
Feb 7, 2020·Eating and Weight Disorders : EWD·Yanran HuJue Chen

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