Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Andreea CorinaPablo Pérez-Martínez

Abstract

Leukocyte telomere length (LTL) shortening is a biomarker of cellular aging that can be decelerated by diet. We aimed to investigate the effect of dietary intake of vitamin E on biomarkers of cellular senescence in patients with established cardiovascular disease. To this end, DNA from 1,002 participants of the CORDIOPREV study (NCT00924937) was isolated and LTL was measured by real-time PCR. Dietary information was collected using a 146-item food frequency questionnaire, and several oxidative stress and damage biomarkers were determined. We found that patients with an inadequate intake of vitamin E according to the European Food Safety Authority, U.S. Food and Nutrition Board, and Spanish dietary recommendation had shorter LTL than those with an adequate intake (p = .004, p = .015, and p = .005, respectively). Moreover, we observed a positive correlation between olive oil, fish consumption and LTL (r2 = .083, p = .010; r2 = .090, p = .006, respectively). Subjects who consumed more than 30 mL olive oil/day had longer LTL than subjects with lower consumption (p = .013). Furthermore, we observed higher glutathione peroxidase activity in subjects consuming less vitamin E (p = .031). Our findings support the importance of an adequa...Continue Reading

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Citations

Jul 6, 2019·Critical Reviews in Food Science and Nutrition·Elena Critselis, Demosthenes Panagiotakos
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Nov 7, 2019·Current Pharmaceutical Design·Andreea CorinaManfredi Rizzo
Jan 31, 2021·European Journal of Clinical Nutrition·Oliver M ShannonJohn C Mathers
Feb 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yanling ShuHuawen Li
Feb 20, 2021·Frontiers in Pharmacology·Maryam AbidizadeganJaanika Blomster

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