Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery

Biomaterials Science
Jianxin LiuPan Li

Abstract

Theranostics is a new trend in the tumor research field, which involves the integration of diagnostic and therapeutic functions using imageable nanoparticles coupled with therapeutic drugs. Imaging-guided targeted delivery of therapeutics and diagnostics using nanocarriers hold great promise to minimize the side effects of conventional chemotherapy. Ultrasound microbubbles have been employed as theranostic agents over the last decade, which provide both real-time dynamic imaging for diagnosis and precise control for targeted tumor therapy. However, the intrinsic defects of microbubbles such as poor tissue penetration, short circulation time and instability hinder microbubble-based theranostic applications. In recent years, liquid-to-gas transitional perfluorocarbon nanoparticles have been developed as promising diagnostic and therapeutic nanoagents to solve the abovementioned problems. In this study, phase-changeable, folate-targeted perfluoropentane nanodroplets loaded with 10-hydroxycamptothecin (HCPT) and superparamagnetic Fe3O4 (denoted as FA-HCPT-Fe3O4-PFP NDs) are prepared and investigated for multimodal tumor imaging and targeted therapy. After intravenous administration into nude mice bearing SKOV3 ovarian cancer, FA-HC...Continue Reading

References

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·M T PeracchiaP Couvreur
Aug 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·C E SomaP Couvreur
May 15, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jun MaRong Wang
Sep 1, 2005·Cancer Chemotherapy and Pharmacology·Thomas SchluepMark E Davis
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Sep 5, 2006·Biophysical Journal·Claus-Dieter OhlDetlef Lohse
Jul 12, 2007·Journal of the National Cancer Institute·Natalya RapoportAnne Kennedy
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Yu-Yuan LiYu-Qiang Nie
May 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya Y RapoportKweon-Ho Nam
Feb 6, 2010·Ultrasound in Medicine & Biology·Natalya RapoportKweon-Ho Nam
Apr 21, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kwangmeyung KimIck Chan Kwon
Feb 1, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya RapoportAnne M Kennedy
Dec 23, 2011·Chemical Society Reviews·Dong-Eun LeeIck Chan Kwon
Jan 3, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ashish RanjanMatthew R Dreher
Jul 10, 2012·Advanced Drug Delivery Reviews·Ju Hee RyuIck Chan Kwon
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pan LiZhigang Wang
Jun 15, 2013·Journal of Nanoscience and Nanotechnology·Yaswanth KuthatiChia-Hung Lee
May 2, 2014·Bioconjugate Chemistry·Caixin GuoZhifei Dai
May 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Siv EggenCatharina de Lange Davies
Oct 22, 2015·Advances in Experimental Medicine and Biology·Natalya Rapoport
Jul 23, 2016·Theranostics·Mark Marty Pagel
Nov 23, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·F Danhier

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Citations

Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao YangHaitao Ran
Feb 23, 2020·Frontiers in Pharmacology·Xiaowen CaiChuanshan Xu
Aug 21, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jinfeng LiaoZhiyong Qian
Nov 20, 2020·Biomaterials Science·Wonseok Choi, Chulhong Kim
Mar 14, 2020·Ultrasound in Medicine & Biology·Klazina KooimanChristy K Holland
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song
Aug 29, 2021·Pharmaceutics·Kristin Entzian, Achim Aigner
Sep 4, 2021·Beilstein Journal of Nanotechnology·Sepand Tehrani FatehAmin Shiralizadeh Dezfuli

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
optical microscopy

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