Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice

Behavioural Brain Research
Dávid CsabaiBoldizsár Czéh

Abstract

Previous data have shown that high dose of nicotine administration or tobacco smoke exposure can reduce cell formation and the survival rate of adult-born neurons in the dentate gyrus. Here, we subjected adult mice to low intensity cigarette smoke exposure over long time periods. We did a 2×30min/day smoke exposure with two cigarettes per occasion over 1- or 2-months. Subsequently, we carried out a systematic quantitative histopathological analysis to assess the number of newborn neurons in the dentate gyrus. To investigate cell proliferation, the exogenous marker 5-bromo-2'-deoxyuridine (BrdU) was administered on the last experimental day and animals were sacrificed 2h later. To investigate the effect of tobacco smoke on the population of immature neurons, we quantified the number of doublecortin-positive (DCX+) neurons in the same animals. We found that exposing animals to cigarette smoke for 1- or 2-months had no influence on cell proliferation rate, but significantly reduced the number of DCX-positive immature neurons. Our tobacco smoke exposure regimen caused no substantial changes in respiratory functions, but histopathological analysis of the pulmonary tissue revealed a marked perivascular/peribronchial edema formation a...Continue Reading

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Citations

Jul 30, 2016·Journal of Alzheimer's Disease : JAD·Timothy C DurazzoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 25, 2017·Neuroscience and Biobehavioral Reviews·Angela IannitelliGiuseppe Bersani
Sep 1, 2017·Toxicology and Industrial Health·Thais Lourenço MartinsFrank Silva Bezerra
Nov 23, 2018·Nature Reviews. Neuroscience·Mireille KhachoRuth S Slack
Nov 5, 2019·Neuroscience Letters·Peiliang WuUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative
Jul 3, 2021·Brain Sciences·Wojciech HajdusianekPaweł Gać

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