Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction.

Cardiovascular Research
Yuto MonmaHiroaki Shimokawa

Abstract

Heart failure with preserved left ventricular ejection fraction (HFpEF) is a serious health problem worldwide, as no effective therapy is yet available. We have previously demonstrated that our low-intensity pulsed ultrasound (LIPUS) therapy is effective and safe for angina and dementia. In this study, we aimed to examine whether the LIPUS therapy also ameliorates cardiac diastolic dysfunction in mice. Twelve-week-old obese diabetic mice (db/db) and their control littermates (db/+) were treated with either the LIPUS therapy [1.875 MHz, 32 cycles, Ispta (spatial peak temporal average intensity) 117-162 mW/cm2, 0.25 W/cm2] or placebo procedure two times a week for 4 weeks. At 20-week-old, transthoracic echocardiography and invasive haemodynamic analysis showed that cardiac diastolic function parameters, such as e', E/e', end-diastolic pressure-volume relationship, Tau, and dP/dt min, were all deteriorated in placebo-treated db/db mice compared with db/+ mice, while systolic function was preserved. Importantly, these cardiac diastolic function parameters were significantly ameliorated in the LIPUS-treated db/db mice. We also measured the force (F) and intracellular Ca2+ ([Ca2+]i) in trabeculae dissected from ventricles. We found t...Continue Reading

References

Oct 8, 1999·The American Journal of Cardiology·S J LesterE Foster
Sep 29, 2001·Science·R G Parton
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Sep 25, 2007·Journal of the American College of Cardiology·Toyotaka YadaFumihiko Kajiya
Nov 9, 2007·Annual Review of Physiology·Donald M Bers
Mar 19, 2011·European Journal of Heart Failure·Yasuharu TakedaKazuhiro Yamamoto
Sep 11, 2014·Cell Calcium·Laetitia PereiraAna María Gómez
Jul 30, 2015·European Journal of Heart Failure·Hiroaki ShimokawaYasuhiko Sakata
Mar 5, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·G ConceiçãoI Falcão-Pires
Apr 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomohiko ShindoHiroaki Shimokawa
May 4, 2016·Translational Andrology and Urology·Zhongcheng XinYinglu Guo
Apr 15, 2017·Circulation Research·Jason RohAnthony Rosenzweig
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shinichiro SunamuraHiroaki Shimokawa
Nov 1, 2018·Physiological Reviews·Jolanda van der Velden, Ger J M Stienen
Feb 9, 2019·Journal of the American College of Cardiology·Kelly McHughAdrian F Hernandez
Apr 9, 2019·European Heart Journal·Filippos TriposkiadisGilles W De Keulenaer
Apr 12, 2019·Nature·Gabriele G SchiattarellaJoseph A Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Experimental Physiology
Danielle SenadorKhalid M Elased
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Hirofumi YamauchiKunio Doi
© 2021 Meta ULC. All rights reserved