Low-intensity pulsed ultrasound enhances bone repair in a rabbit model of steroid-associated osteonecrosis

Clinical Orthopaedics and Related Research
Han-Xiao ZhuShi-Gui Yan

Abstract

Steroids are a leading cause of femoral head osteonecrosis. Currently there are no medications available to prevent and/or treat steroid-associated osteonecrosis. Low-intensity pulsed ultrasound (LIPUS) was approved by the FDA for treating delayed union of bone fractures. Some studies have reported that LIPUS can enhance bone formation and local blood flow in an animal model of fracture healing. However, whether the effect of osteogenesis and neovascularization by LIPUS can enhance the repair progress in steroid-associated osteonecrosis is unknown. We hypothesized that LIPUS may facilitate osteogenesis and neovascularization in the reparative processes of steroid-associated osteonecrosis. Using a rabbit animal model, we asked whether LIPUS affects (1) bone strength and trabecular architecture; (2) blood vessel number and diameter; and (3) BMP-2 and VEGF expression. Bilateral femoral head necrosis was induced by lipopolysaccharide and methylprednisolone in 24 rabbits. The left femoral heads of rabbits received LIPUS therapy (200 mW/cm(2)) for 20 minutes daily and were classified as the LIPUS group. The right femoral heads of the same rabbits did not receive therapy and were classified as the control group. All rabbits were eutha...Continue Reading

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Jun 11, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xuan ZhangJinlin Song
Jan 25, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Suiyi WuTianming Xu
Feb 6, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shengyang JinHong Wang
Feb 6, 2020·Clinical Orthopaedics and Related Research·Hyuck Min KwonWoo-Suk Lee
Aug 1, 2020·Clinical Orthopaedics and Related Research·Hyuck Min KwonWoo-Suk Lee
Jan 16, 2021·Cell Proliferation·Jiankang ZhangWei Jing

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