Low-intensity treadmill exercise promotes rat dorsal wound healing

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Wu ZhouShu-Nan Ye

Abstract

In order to investigate the promoting effect of low-intensity treadmill exercise on rat dorsal wound healing and the mechanism, 20 Sprague-Dawley rats were randomly divided into two groups: exercise group (Ex) and non-exercise group (non-ex). The rats in Ex group were given treadmill exercise for one month, and those in non-ex group raised on the same conditions without treadmill exercise. Both groups received dorsal wound operation with free access to food and water. By two-week continuous observation and recording of the wound area, the healing rate was analyzed. The blood sample was collected at day 14 post-operation via cardiac puncture for determination of the number of endothelial progenitor cells (EPCs) by flow cytometry, and the concentrations of relevant cytokines such as basic fibroblast growth factor (bFGF), endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) were measured by ELISA. The skin tissue around the wound was dissected to observe the vascular density under the microscope after HE staining, to detect the mRNA level of VEGFR2 and angiopoietin-1 (Ang-1) receptor using RT-qPCR, and protein expression of a-smooth muscle actin (αSMA) and type III collagen (ColIII) using Western ...Continue Reading

References

Jun 15, 2004·Journal of the American College of Cardiology·Jalees RehmanKeith L March
Oct 28, 2005·The American Journal of Pathology·Traci A WilgusLuisa A DiPietro
Nov 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Todd KeylockJeffrey A Woods
Oct 23, 2008·Tissue Engineering. Part a·Paul Van SlykeDan Dumont
May 1, 2012·Medicine and Science in Sports and Exercise·Brandt D PenceJeffrey A Woods
Feb 19, 2013·Journal of Cellular and Molecular Medicine·Xiaoren TangSalomon Amar
Apr 10, 2013·Gene·Anna Grochot-PrzeczekAlicja Jozkowicz
Oct 24, 2013·Advances in Skin & Wound Care·Kevin Y WooAfsaneh Alavi

❮ Previous
Next ❯

Citations

Apr 14, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shao-Wei YangXiao-Bing Fu
Jun 20, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bianca O SaguieAndréa Monte-Alto-Costa
Apr 15, 2020·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Grace A Kanzawa-Lee
Jan 22, 2020·Seminars in Oncology Nursing·Robert KnoerlEllen M Lavoie Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.