Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications

Brain Stimulation
Anton FomenkoAndres M Lozano

Abstract

There is an emerging need for noninvasive neuromodulation techniques to improve patient outcomes while minimizing adverse events and morbidity. Low-intensity focused ultrasound (LIFUS) is gaining traction as a non-surgical experimental approach of modulating brain activity. Several LIFUS sonication parameters have been found to potentiate neural firing, suppress cortical and epileptic discharges, and alter behavior when delivered to cortical and subcortical mammalian brain regions. This review introduces the elements of an effective sonication protocol and summarizes key preclinical studies on LIFUS as a neuromodulation modality. The state of the art in human ultrasound neuromodulation is then comprehensively summarized, and current hypotheses regarding the underlying mechanism of action on neural activity are presented. Peer-reviewed literature on human ultrasound neuromodulation was obtained by searching several electronic databases. The abstracts of all reports were read and publications which examined low-intensity transcranial ultrasound applied to human subjects were selected for review. LIFUS can noninvasively influence human brain activity by suppressing cortical evoked potentials, influencing cortical oscillatory dynam...Continue Reading

Citations

Dec 14, 2019·Annals of Biomedical Engineering·Taewon ChoiJinhyoung Park
Jun 13, 2020·Journal of Cognitive Neuroscience·Til Ole Bergmann, Gesa Hartwigsen
May 16, 2019·Neural Regeneration Research·Anton Fomenko, Andres M Lozano
Jul 17, 2020·Science Advances·Jan KubanekWilliam Newsome
Dec 14, 2018·Frontiers in Neurology·Benjamin C GibsonVincent P Clark
Mar 26, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D PaladiniA Rossi
Oct 20, 2020·The Journal of General Physiology·Martin Loynaz PrietoMerritt Maduke
Jan 20, 2020·Neuroscience Research·Yuichi Takeuchi, Antal Berényi
Sep 17, 2020·Science Advances·Jan KubanekWilliam Newsome
May 4, 2021·NeuroImage·Til Ole BergmannHartwig Roman Siebner
Jun 17, 2021·Ultrasound in Medicine & Biology·Natalia Dos Santos TramontinAlexandre Pastoris Muller
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fiona Permezel
Dec 3, 2021·The American Journal of Psychiatry·Susan K Conroy, Paul E Holtzheimer
Jan 14, 2022·Translational Vision Science & Technology·Matthieu ProvansalSerge Picaud

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