Low intrathecal antibody production despite high seroprevalence of Epstein-Barr virus in multiple sclerosis: a review of the literature

Journal of Neurology
Klemens RuprechtSven Jarius

Abstract

Patients with multiple sclerosis (MS) frequently have an intrathecal production of antibodies to different common viruses, which can be detected by elevated antiviral antibody indices (AIs). There is a strong and consistent association of MS and Epstein-Barr virus (EBV) infection. To systematically compare the frequencies of intrathecal antibody production to EBV, measles virus, rubella virus, varicella zoster virus (VZV) and herpes simplex virus (HSV) in patients with MS. Review of the English and German literature on the frequencies of intrathecal immunoglobulin (Ig)G antibody production, as defined by an elevated AI, to EBV, measles virus, rubella virus, VZV and HSV in adult and pediatric patients with MS. In nine original studies identified, the frequencies of an intrathecal production of antibodies to Epstein-Barr nuclear antigen-1 (33/340, 9.7%), EBV viral capsid antigen (12/279, 4.3%) and antigens from EBV-infected cell lines (14/90, 15.6%) in adult patients with MS were clearly lower (p ≤ 0.03 for all pairwise comparisons) than the frequencies of an intrathecal production of antibodies to measles virus (612/922, 66.4%), rubella virus (521/922, 56.5%), VZV (470/922, 51%; data from 17 original studies) and HSV (78/291, 26...Continue Reading

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Citations

Feb 13, 2018·Apoptosis : an International Journal on Programmed Cell Death·Ingo GerhauserAndreas Beineke
Jun 18, 2020·Viruses·Rachael E TarlintonSubhash Verma
Nov 6, 2020·Expert Review of Clinical Immunology·Klemens Ruprecht
Jan 5, 2021·Frontiers in Immunology·Gunnar HouenJette Lautrup Frederiksen
Jan 28, 2021·Archives of Virology·Jéssica WoukLigia Carla Faccin-Galhardi
Aug 26, 2021·Neurology. Neuroimmunology and Neuroinflammation·Philipp SchwenkenbecherUNKNOWN German Network for Research on Autoimmune Encephalitis

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