Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity.

Basic Research in Cardiology
Michael SchwarzerTorsten Doenst

Abstract

In patients, inactivity, obesity and insulin resistance are associated with increased incidence of heart failure. Rats selectively bred for low (LCR) intrinsic aerobic exercise capacity show signs of the metabolic syndrome including insulin resistance, compared to their counterparts bred for high intrinsic aerobic capacity (HCR). We reasoned that systemic insulin resistance in LCR should translate to impaired substrate oxidation and reduced insulin sensitivity in the heart. Isolated hearts were perfused in the working mode to analyze cardiac function, substrate oxidation patterns, insulin response, and oxygen consumption. After 22 generations of selective breeding, LCR displayed reduction of exercise capacity (LCR vs. HCR: distance 280 +/- 12 vs. 1,968 +/- 63 m, time 19.5 +/- 0.6 vs. 71.7 +/- 1.4 min, speed 19.2 +/- 0.3 vs. 45.3 +/- 0.7 m/min; all p < 0.05). At 21 weeks, body weight (+34%), tibia length (+6%), heart weight (+31%), and heart weight to tibia length ratio (+24%; all p < 0.05) were increased. LCR display higher random glucose, higher fasting glucose, and higher insulin levels in serum than HCR indicating the presence of insulin resistance in LCR. Here, in contrast, isolated hearts showed no differences in glucose (...Continue Reading

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Citations

Dec 25, 2010·Basic Research in Cardiology·L BiletV B Schrauwen-Hinderling
Aug 30, 2011·Journal of Molecular and Cellular Cardiology·M LenskiU Laufs
Nov 22, 2011·Journal of Molecular and Cellular Cardiology·Andrea SchrepperTorsten Doenst
May 28, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Amanda L SharpeGlenn M Toney
Dec 13, 2016·Journal of Proteome Research·Oluyemi S FaleganJane Shearer
Jul 24, 2021·Physiological Genomics·Michael SchwarzerTorsten Doenst

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