Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Laudine CommunalAnne-Marie Mes-Masson

Abstract

High-grade serous carcinoma of uterine adnexa (HGSC) is the most frequent histotype of epithelial ovarian cancer and has a poor 5-year survival rate due to late-stage diagnosis and the poor efficacy of standard treatments. Novel biomarkers of cancer outcome are needed to identify new targetable pathways and improve personalized treatments. Cell-surface screening of 26 HGSC cell lines by high-throughput flow cytometry identified junctional adhesion molecule 1 (JAM-A, also known as F11R) as a potential biomarker. Using a multi-labeled immunofluorescent staining coupled with digital image analysis, protein levels of JAM-A were quantified in tissue microarrays from three HGSC patient cohorts: a discovery cohort (n = 101), the Canadian Ovarian Experimental Unified Resource cohort (COEUR, n = 1158), and the Canadian Cancer Trials Group OV16 cohort (n = 267). Low JAM-A level was associated with poorer outcome in the three cohorts by Kaplan-Meier (p = 0.023, p < 0.001, and p = 0.036, respectively) and was an independent marker of shorter survival in the COEUR cohort (HR = 0.517 (0.381-703), p < 0.001). When analyses were restricted to patients treated by taxane-platinum-based chemotherapy, low JAM-A protein expression was associated wi...Continue Reading

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·Laudine CommunalAnne-Marie Mes-Masson
Sep 18, 2021·Molecular and Cellular Biochemistry·Kamila Czubak-ProwizorMaria Swiatkowska

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BETA
flow cytometry

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FACSDiva
JetSet
xvViewer
Graphpad Prism
SPSS
Visiopharm® ( VP )
OlyVIA® viewer
Visiopharm®

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