Low LDL oxidation in veteran endurance athletes

Scandinavian Journal of Medicine & Science in Sports
U M KujalaM J Tikkanen

Abstract

The 'oxidation hypothesis' states that oxidative modification of low-density lipoprotein (LDL) is important in the pathogenesis of the atherosclerotic lesion. Physical exercise has been reported to reduce clinical manifestations of atherosclerosis. We compared the effects of aerobic physical exercise history on oxidation characteristics of plasma LDL at rest in non-smoking male veteran endurance athletes (n= 15) and control subjects (n= 16). As an indicator of LDL oxidation we used a method which provides an estimate of LDL diene conjugation in vivo. The athletes had lower plasma LDL cholesterol diene conjugation (P=0.003). They also had lower cholesterol, lower LDL and higher high-density lipoprotein (HDL) cholesterol. Intensive physical exercise energy expenditure correlated inversely with LDL diene conjugation (r=-0.41, P= 0.021). We conclude that participation in intensive physical exercise training is associated with reduced plasma LDL fraction oxidation as reflected by LDL diene conjugation. This finding may have relevance for studies aiming to explain the variation in occurrence of ischemic heart disease.

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Citations

Oct 28, 1998·Medicine and Science in Sports and Exercise·T J VasankariM Ahotupa
Sep 29, 2011·Medicine and Science in Sports and Exercise·Jussi KosolaTommi Vasankari
Jul 23, 1999·Medicine and Science in Sports and Exercise·U M KujalaJ Karjalainen
Jan 5, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Gene R Herzberg
Apr 11, 2006·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Jyrki A KettunenSeppo Sarna
Sep 15, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E PihlM Zilmer
Jun 19, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T VasankariM Ahotupa
Jun 5, 2017·BMC Research Notes·Jobert Richie NansseuJeanne Y Ngogang
Jul 1, 1998·Clinical Biochemistry·M AhotupaS Ylä-Herttuala
Aug 5, 2000·Atherosclerosis·T VasankariJ Viikari
Feb 21, 2006·Life Sciences·Fernando BritesLaura Schreier

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