Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study

Maternal & Child Nutrition
Jef L LeroyJia-Sheng Wang

Abstract

Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk-based multiple micronutrient-fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1 -lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household-level covariates. AFB1 -lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB1 -lysine/mg albumin) was associated (p < .05) with an increase in the child's height-for-age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow-up (average age 12 months); the magnitude of the difference in the...Continue Reading

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Citations

Mar 4, 2020·Toxins·Beatriz Arce-LópezElena González-Peñas
Dec 12, 2019·Maternal & Child Nutrition·Simone PassarelliWafaie Fawzi
Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Heather Wallace
Nov 7, 2019·Critical Reviews in Food Science and Nutrition·Kokeb TesfamariamCarl Lachat
May 30, 2020·Environmental Science and Pollution Research International·Lorena Díaz de León-MartínezRogelio Flores-Ramírez
Oct 8, 2020·Archives of Environmental & Occupational Health·Esra Yasemin MemişSuzan Yalçın
Oct 8, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ruth Nabwire Wangia-DixonJia-Sheng Wang
Mar 8, 2021·The American Journal of Clinical Nutrition·Johanna Y Andrews-TrevinoShibani Ghosh
Feb 2, 2021·Public Health Nutrition·Masresha TessemaNilupa S Gunaratna

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