Low-level contamination of deoxynivalenol: A threat from environmental toxins to porcine epidemic diarrhea virus infection.

Environment International
Dandan LiuKehe Huang

Abstract

Mycotoxins are toxic metabolites produced by fungal species that commonly present in the global environment, especially in cereals and animal forages. The changing global environment may further increase the exposure to these toxins, posing a serious threat to humans and animals. Recently, coronavirus has become one of the most important pathogens threatening human and animal health. It is not clear whether environmental toxins, such as mycotoxins, will affect coronavirus infection. Given that pigs are among the animals most affected by coronavirus and highly homologous to humans, weaned piglets and IPEC-J2 cells were respectively chosen as in vivo and in vitro model to explore the impacts of deoxynivalenol (DON), the most abundant trichothecene mycotoxin in feed, on porcine epidemic diarrhea virus (PEDV) infection and the mechanisms involved. In vivo, twenty-seven piglets infected naturally with PEDV were randomly divided into three groups, receiving the basal diet containing 0, 750 and 1500 μg/kg DON, respectively. Significant increases in the diarrhea rates, gut barrier injury and PEDV proliferation of piglets' small intestine were observed in experimental groups compared with the control. Additionally, the autophagosome-lik...Continue Reading

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Citations

Sep 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei GeKehe Huang

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Methods Mentioned

BETA
PCR
coimmunoprecipitation
transfection
transmission electron microscopy
co-immunoprecipitation

Software Mentioned

Image Quant
Invitrogen
Image Pro - Plus
Graph Pad Prism

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