Low-level exposure to cadmium during the lifetime increases the risk of osteoporosis and fractures of the lumbar spine in the elderly: studies on a rat model of human environmental exposure

Toxicological Sciences : an Official Journal of the Society of Toxicology
Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk

Abstract

In this study, based on a rat model of human environmental exposure to cadmium (Cd), it has been examined whether low-level lifetime Cd exposure increases the risk of vertebral osteoporosis and vertebrae fractures in the elderly. For this purpose, the lumbar vertebral bodies (L4 or L3) of control and Cd-exposed (1 mg Cd/l in drinking water for 24 months) female Wistar rats were assigned to densitometric, radiographic, biomechanical (compression test), and biochemical studies, as well as to assess their dimensions and chemical composition. The exposure to Cd affected the mineral status of the L4. The decreased mineral content, density (BMD) and bone mineral area of the vertebral body together with the unchanged ratio of non-organic and organic components indicate osteoporotic nature of the Cd-induced changes. The activity of alkaline phosphatase in the L3 decreased. Cd also influenced the mechanical properties of the L4. The yield load and ultimate load decreased indicating a weakness in the vertebral body compression strength. Stiffness of the L4 decreased and the displacement at ultimate increased suggesting its enhanced susceptibility to deformities. Indeed, in the Cd group vertebral deformities (in 30% of females) or even fr...Continue Reading

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Citations

May 20, 2005·Archives of Toxicology·Małgorzata M BrzóskaJanina Moniuszko-Jakoniuk
Jun 30, 2005·Archives of Toxicology·Małgorzata M BrzóskaJanina Moniuszko-Jakoniuk
Jun 9, 2005·Archives of Toxicology·Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk
Sep 1, 2005·Toxicology and Applied Pharmacology·Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk
Apr 20, 2005·Toxicology Letters·Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk
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