Low-level laser therapy for prevention of noise-induced hearing loss in rats

Neuroscience Letters
Atsushi TamuraAkihiro Shiotani

Abstract

Noninvasive low-level laser therapy (LLLT) is neuroprotective, but the mechanism of this effect is not fully understood. In this study, the use of LLLT as a novel treatment for noise-induced hearing loss (NIHL) is investigated. Sprague-Dawley rats were exposed to intense noise and their right ears were irradiated with an 808nm diode laser at an output power density of 110 or 165mW/cm(2) for a 30min period for 5 consecutive days. Measurement of the auditory brainstem response revealed an accelerated recovery of auditory function in the groups treated with LLLT compared with the non-treatment group at days 2, 4, 7 and 14 after noise exposure. Morphological observations also revealed a significantly higher outer hair cell survival rate in the LLLT groups. Immunohistochemical analyses for inducible nitric oxide synthase (iNOS) and cleaved caspase-3 were used to examine oxidative stress and apoptosis. Strong immunoreactivities were observed in the inner ear tissues of the non-treatment group, whereas these signals were decreased in the LLLT group at 165mW/cm(2) power density. Our findings suggest that LLLT has cytoprotective effects against NIHL via the inhibition of iNOS expression and apoptosis.

References

Jan 1, 1979·Archives of Oto-rhino-laryngology·E HultcrantzM Beausang-Linder
May 1, 1996·Journal of Clinical Periodontology·M J ConlanC M Cobb
Aug 7, 1999·Audiology & Neuro-otology·K K OhlemillerL L Dugan
Jan 18, 2002·Current Opinion in Neurology·Masaya Takumida, Matti Anniko
Oct 10, 2003·Journal of the Association for Research in Otolaryngology : JARO·Thomas M NicoteraDonald Henderson
Oct 6, 2005·European Journal of Pharmacology·Kuniyoshi TanakaHiroshi Yamashita
Jul 31, 2008·Photomedicine and Laser Surgery·R TeggiM Bussi
Dec 17, 2009·Dose-response : a Publication of International Hormesis Society·Ying-Ying HuangMichael R Hamblin
Jul 28, 2010·Lasers in Surgery and Medicine·Yoichi UozumiMakoto Kikuchi
Jun 13, 2012·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shunta InaiKimihiro Okubo
Jun 28, 2012·Journal of Biomedical Optics·Chung-Ku RheeMyung-Whan Suh
Jan 1, 2012·ISRN Otolaryngology·Ahmed H SalahaldinAbdulbari Bener

❮ Previous
Next ❯

Citations

Oct 22, 2016·Neuroscience Letters·Min Young LeeJae Yun Jung
Nov 23, 2017·Photochemistry and Photobiology·Michael R Hamblin
Jan 8, 2019·International Journal of Radiation Biology·Ruwaidah A MussttafAwadhesh N Jha
Aug 29, 2019·Biomedical Engineering Letters·Jae-Hun LeeMin Young Lee
Aug 23, 2019·Journal of Biomedical Optics·Katharina SorgGentiana I Wenzel
Dec 5, 2019·The Journal of the Acoustical Society of America·Avril Genene HoltRichard Altschuler
Dec 31, 2020·Journal of Speech, Language, and Hearing Research : JSLHR·Maria Carolina FerreiraMaria Fernanda Capoani Garcia Mondelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Xu-Dong Li, Yi-Min Liu
© 2021 Meta ULC. All rights reserved