Low-level lead exposure selectively enhances dopamine overflow in nucleus accumbens: an in vivo electrochemistry time course assessment

Toxicology and Applied Pharmacology
C L ZuchDeborah A Cory-Slechta

Abstract

Exposures to even very low levels of lead (Pb) alter behavioral and neurochemical functions. The current study was based on the hypothesis that excess synaptic dopamine (DA) availability may contribute to such disturbances and that the mesolimbic DA projection is more sensitive than the nigrostriatal system to Pb-induced DA-based alterations. In vivo electrochemical measurements of potassium chloride-evoked DA overflow and clearance were compared in dorsal striatum (STR) (nigrostriatal system) and nucleus accumbens (NAC)(mesolimbic system) of male rats after 11 weeks or 11 months of postweaning exposure to 0, 50, or 150 ppm Pb acetate drinking solutions. Pb increased evoked DA overflow selectively in NAC, with biphasic effects at 11 weeks, including increases greater than 400% at 50 ppm and concentration-related effects up to 265% of control at 11 months. Considered relative to 11-week control levels, continued exposure tended to attenuate the magnitude of Pb-related increases in DA overflow in NAC. Pb decreased clearance time in both brain regions, with these effects markedly augmented across time. These changes in DA function were observed at blood Pb values of only 15-16 micrograms/dl, underscoring their environmental releva...Continue Reading

References

Jan 1, 1979·Toxicology and Applied Pharmacology·D A Cory-Slechta, T Thompson
Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
Mar 1, 1992·Neurobiology of Aging·M N Friedemann, G A Gerhardt
Jan 11, 1990·The New England Journal of Medicine·H L NeedlemanE N Allred
Jan 1, 1987·Journal of Neural Transmission·A C BartonK T Demarest
May 1, 1988·Neuroscience·C A MarsdenJ A Stamford
Sep 30, 1988·Toxicology and Applied Pharmacology·S M Lasley, J D Lane
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 23, 1987·The New England Journal of Medicine·D BellingerM Rabinowitz
May 1, 1987·Neurobiology of Aging·H H McIntosh, T C Westfall
Apr 1, 1985·Toxicology and Applied Pharmacology·D A Cory-SlechtaC Cox
Jan 1, 1973·Clinical Toxicology·G A Van GelderW B Buck
Jan 1, 1973·Clinical Toxicology·N N Scharding, F W Oehme
Jan 9, 1984·Brain Research·G A GerhardtR N Adams
Mar 1, 1983·Neuropathology and Applied Neurobiology·C WinderP D Lewis
Dec 1, 1995·Journal of Neurochemistry·M F Suaud-ChagnyF Gonon
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·W S EnochsH M Swartz
Mar 1, 1995·Neurobiology of Aging·R D BurwellM Gallagher
Dec 1, 1994·Current Opinion in Neurology·C W Olanow, G W Arendash
Jan 1, 1994·Pharmacology & Therapeutics·M E GötzM B Youdim

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Citations

Jul 16, 2011·Development and Psychopathology·Robert-Paul JusterSonia J Lupien
Jul 28, 2004·Developmental Neuropsychology·Richard L CanfieldDeborah A Cory-Slechta
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Jan 6, 2011·Environmental Health Perspectives·Ananya RoyKalpana Balakrishnan
May 4, 2004·Environmental Health Perspectives·Deborah A Cory-SlechtaMark R Bauter
Sep 21, 2013·Annual Review of Pharmacology and Toxicology·Samuel M Goldman
May 16, 2003·Pharmacology & Toxicology·Soheila Fazli-TabaeiMohammad-Reza Zarrindast
Jan 29, 2014·Environmental Science and Pollution Research International·Lian LiuXia Huo
Oct 23, 2015·Chemical Reviews·Ju MeiBen Zhong Tang
Jan 23, 2017·Environmental Research·Juliana N Souza-TalaricoSonia J Lupien
Jan 9, 2016·Metallomics : Integrated Biometal Science·Jacqueline Michelle Ordemann, Rachel Narehood Austin
Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miriam B VirgoliniDeborah A Cory-Slechta
Jun 20, 2014·Environmental Toxicology·Talia SandersPaul B Tchounwou
Nov 20, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mahboubeh Tavakoli-Nezhad, David K Pitts
Feb 13, 2016·Current Opinion in Pediatrics·Amirhossein ModabberniaAbraham Reichenberg
Jun 17, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·A ModabberniaA Reichenberg
Dec 29, 2018·JAMA Pediatrics·Consuelo M Beck-Sagué, Tomás R Guilarte
Mar 18, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrycja KupnickaIrena Baranowska-Bosiacka
Nov 5, 2005·Pharmacology, Biochemistry, and Behavior·M CorreaC M G Aragon
Aug 3, 2019·Environmental Science & Technology·Andrea S GrunstMarcel Eens

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