Low level nicotine: a novel approach to reduce osteoporosis incidence

Medical Hypotheses
Jun ZhangJinping Chen

Abstract

Osteoporosis is a serious health problem worldwide and leads to a significant burden on society. Unfortunately, efforts to control osteoporosis are largely unsuccessful. Lowering an individual's risk for osteoporosis must focus not only on treatment but also on modification of risk factors. One of the common risk factors is smoking tobacco. Here, we review the clinical evidence on nicotine consumption and osteoporosis, and propose a possible protective mechanism. It should be note that there is no strong clinical evidence that proves nicotine is detrimental. Studies also indicated that the prime criminal for osteoporosis is smoking not nicotine. Moreover, low level nicotine has preventive efforts on osteoporosis by stimulating osteoblasts proliferation and differentiation. We present a hypothesis that low level nicotine may be a novel approach to reduce osteoporosis incidence.

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Citations

Sep 8, 2012·Archives of Gynecology and Obstetrics·Volkan TuranGulinnaz Ercan
May 9, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Santiago PalaciosZion Ben-Rafael
Feb 16, 2013·Expert Opinion on Drug Safety·Rami KallalaPeter V Giannoudis
May 11, 2010·Medical Hypotheses·Jun ZhangJinping Chen
Mar 12, 2010·Medical Hypotheses·M C Gracia
Mar 2, 2011·Drug and Alcohol Review·Kenneth M Dürsteler-MacFarlandRudolf Stohler

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