Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne

Lasers in Surgery and Medicine
Wen-Hwa LiMichael D Southall

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm2have demonstrated marked effects on inflammatory acne lesions. However, few studies have investigated the effects of lower doses of light. The aim of this study is to investigate the biological effects of lower doses of red light at 0.2-1.2 J/cm2for acne using an in vitro model previously developed to mimic the inflammation and hyperkeratinization observed clinically in acne. Human epidermal equivalents were topically exposed to an unsaturated fatty acid, oleic acid (OA), followed by red light-emitting diode (LED) light treatments (light-plus-OA treatments). Endpoints evaluated included the proinflammatory cytokine IL-1α, epidermal barrier integrity, as measured by transepithelial electrical resistance (TEER), and stratum corneum (SC) thickness to monitor hyperkeratinization. OA-induced IL-1α release ...Continue Reading

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Citations

Mar 29, 2019·Lasers in Surgery and Medicine·Jeffrey M BoydAli Fassih
Jul 17, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K Y ParkN-K Rho
Sep 8, 2019·Lasers in Surgery and Medicine·Thamires R de SouzaElaine C de Oliveira Guirro
Aug 26, 2018·Lasers in Medical Science·Ali Rajabi-EstarabadiKeyvan Nouri
May 8, 2021·The Journal of Dermatological Treatment·Chanoknan JornsamerPawinee Rerknimitr
Sep 3, 2021·Clinical, Cosmetic and Investigational Dermatology·Anna SzymańskaAnna Erkiert-Polguj
Nov 7, 2021·Annals of the New York Academy of Sciences·Rong RongDan Ji

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