Low levels of ApoA1 improve risk prediction of type 2 diabetes mellitus

Journal of Clinical Lipidology
Xing WuXue-Qiao Zhao

Abstract

Type 2 diabetes mellitus (T2DM) has reported to be a major public health crisis in China. We examined the incidence of new T2DM over 4 years for association of clinical factors and lipids with development of T2DM in a community-based population. We included 923 Chinese subjects who participated in community-organized health checkout in both 2009 and 2013. Health history was collected; physical examination was performed; biochemistry, lipids, and glucose were measured. Of 923, 819 were confirmed without T2DM in 2009 and included in the analysis. Unadjusted and adjusted logistic regression models were used to estimate the effects of clinical factors and biomarkers on the risk of new T2DM. Of 819 subjects without T2DM in 2009, 65 were identified as T2DM in 2013, 8% over 4 years. These 65 subjects, compared with those 754 without new T2DM, were older, more likely to be male and smokers. They had higher body mass index (BMI), fasting glucose, blood pressure and triglycerides, and lower levels of high-density lipoprotein-cholesterol and apolipoprotein A1 (ApoA1). Multivariate logistic regression identified larger BMI (odds ratio [OR] = 1.7; 95% confidence interval [CI], 1.22-2.39, P = .002), higher fasting glucose levels (OR = 4.2, 9...Continue Reading

Citations

Jan 12, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O N Poteryaeva, I F Usynin
Nov 26, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Oktawia NilssonJens O Lagerstedt
May 1, 2021·Cells·Blake J CochranKerry-Anne Rye
Apr 20, 2021·Journal of Proteome Research·Maxime R Eveque-MourrouxBerta Cillero-Pastor
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Liliane de Paula SilvaDayane Alberton

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