Low levels of microbial translocation marker LBP are associated with sustained viral response after anti-HCV treatment in HIV-1/HCV co-infected patients

PloS One
Jessica NyströmPiotr Nowak

Abstract

Microbial translocation (MT) contributes to immune activation during HIV and HCV infections. We investigated the kinetics of MT markers during anti-HCV and anti-HIV treatments, and if baseline plasma levels of lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) could predict anti-HCV treatment outcome. Plasma from 78 HIV-infected patients was evaluated for LPS, LBP and sCD14. The patients starting anti-HCV treatment (with ongoing antiretroviral (ART) treatment) were categorized into sustained viral responders (SVR; n = 21) or non-responders (NR; n = 15) based on treatment outcome. ART starting subjects--were categorized into chronically HCV-infected (CH; n = 24) and mono-infected (HIV; n = 18), based on the HCV infection status. Samples were collected before start (at baseline) of pegylated-interferon-alpha/ribavirin (peg-IFN/RBV) or antiretroviral-therapy and two years after treatment start (at follow up). χ2-test, non-parametric statistics and logistic regression were applied to determine the associations with treatment response and changes of the soluble markers. Plasma levels of LPS and sCD14 were elevated in all subjects before antiviral-treatment but remained unchanged at follow-up....Continue Reading

References

Oct 1, 1987·The Tohoku Journal of Experimental Medicine·K NakagawaY Yajima
Dec 1, 1995·Archives of Microbiology·J SchletterE T Rietschel
Sep 1, 1996·Journal of Clinical Microbiology·L StuyverG Maertens
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Javier FernándezJuan Rodés
Nov 14, 2002·Bulletin of Experimental Biology and Medicine·A S Sozinov
Nov 20, 2002·World Journal of Gastroenterology : WJG·De-Wu Han
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Agustín AlbillosMelchor Alvarez-Mon
Jan 22, 2004·Journal of Endotoxin Research·Theresa L GioanniniJerrold P Weiss
Jan 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fuyumi IsayamaMichael D Wheeler
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongjin HuangRamsey C Cheung
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe
Dec 7, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·W G ShinC K Park
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan BerenguerSalvador Resino
Jun 25, 2009·Gastroenterology·Arthur Y Kim, Raymond T Chung
Sep 12, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Judith M HaissmanHenrik Ullum
Mar 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Adam AnasAlex F de Vos
Oct 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas J UrbanNezam Afdhal
Jan 27, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Montserrat Montes de Oca ArjonaJose Antonio Giron-González
Apr 9, 2011·Biomarkers in Medicine·Gregor F LichtfussSharon R Lewin
Apr 29, 2011·Digestive Diseases and Sciences·Amy G ShahRichard K Sterling
Sep 16, 2011·Current Opinion in HIV and AIDS·Emma E PagePeter Kelleher
Oct 18, 2011·Current Opinion in HIV and AIDS·Maria D Hernandez, Kenneth E Sherman

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
ELISA
genotyping

Software Mentioned

Graph Pad Prism
Stata

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.