Low levels of mtDNA deletion mutations in ETS normal fibers from aged rats

Annals of the New York Academy of Sciences
Jeong W Pak, J M Aiken

Abstract

The objectives were (1) to determine whether deletion mutations occur in phenotypically normal type I and type II fibers, (2) to quantify the levels of both deletion mutant and wild-type (wt) mtDNA (nondeletion) within single normal fibers containing mutant mtDNA, and (3) to quantify the amount of wt mtDNA in genotypically and phenotypically normal type I and type II fibers. Deletion mutations in normal fibers are not restricted to specific fiber types, although clonal accumulation of mtDNA deletion mutations and subsequent ETS abnormalities occur exclusively in type II fibers.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J HayashiI Nonaka
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·J Müller-HöckerB Kadenbach
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J WanagatJ M Aiken
May 17, 2002·Journal of Applied Physiology·Entela A BuaJudd M Aiken
Dec 7, 2002·The Biochemical Journal·Rodrigue RossignolThierry Letellier

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Citations

Sep 8, 2005·Rejuvenation Research·Rafal M Smigrodzki, Shaharyar M Khan
Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David J BakerRussell T Hepple
May 23, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marta Gonzalez-FreireLuigi Ferrucci
May 2, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Allen HerbstJonathan Wanagat

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