Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia

Journal of Psychiatry & Neuroscience : JPN
Elizabeth ScarrBrian Dean

Abstract

Results of neuroimaging and postmortem studies suggest that people with schizophrenia may have lower levels of muscarinic M1 receptors (CHRM1) in the cortex, but not in the hippocampus or thalamus. Here, we use a novel immunohistochemical approach to better understand the likely cause of these low receptor levels. We determined the distribution and number of CHRM1-positive (CHRM1+) neurons in the cortex, medial dorsal nucleus of the thalamus and regions of the hippocampus from controls (n = 12, 12 and 5, respectively) and people with schizophrenia (n = 24, 24 and 13, respectively). Compared with controls, levels of CHRM1+ neurons in people with schizophrenia were lower on pyramidal cells in layer III of Brodmann areas 9 (-44%) and 17 (-45%), and in layer V in Brodmann areas 9 (-45%) and 17 (-62%). We found no significant differences in the number of CHRM1+ neurons in the medial dorsal nucleus of the thalamus or in the hippocampus. Although diagnostic cohort sizes were typical for this type of study, they were relatively small. As well, people with schizophrenia were treated with antipsychotic drugs before death. The loss of CHRM1+ pyramidal cells in the cortex of people with schizophrenia may underpin derangements in the cholin...Continue Reading

Citations

Jul 28, 2019·The Australian and New Zealand Journal of Psychiatry·Alexander E RyanJudith M Greer
Aug 21, 2019·The International Journal of Neuropsychopharmacology·Shaun HopperBrian Dean
Nov 26, 2020·International Journal of Molecular Sciences·Paulina Cieślik, Joanna M Wierońska
Jun 27, 2019·Progress in Retinal and Eye Research·Muneeb A FaiqKevin C Chan

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