PMID: 11341503May 9, 2001Paper

Low levels of thrombin activatable fibrinolysis inhibitor (TAFI) in patients with chronic liver disease

Thrombosis and Haemostasis
D H Van ThielJ Fareed

Abstract

Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a 60 kappaD glycoprotein present in plasma that regulates fibrinolysis by limiting the amount of fibrin available for fibrinolysis by tissue plasminogen activator (t-PA). Chronic liver disease is well-known to be associated with a low-grade fibrinolytic syndrome that under the appropriate stimulus proceeds to an overt disseminated intravascular coagulopathy (DIC) with demonstrable bleeding. In the present study, TAFI activity was measured in the plasma of 74 patients with advanced liver disease, and the levels of TAFI were related to those of other important coagulation and fibrinolytic factors. TAFI levels were very low and essentially undetectable in the plasma of patients with advanced hepatocellular liver disease. No relationship with the degradation products of fibrin was evident.

Citations

Jul 20, 2002·Journal of Hepatology·Ton LismanPhilip G de Groot
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Francesca Romana PonzianiAntonio Gasbarrini
Jan 20, 2009·Clinics in Liver Disease·Domenico FerroFrancesco Violi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mario ColucciPaolo Gresele
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Stephen H CaldwellCoagulation in Liver Disease Group
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A OrdinasJ Rodés
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Armando TripodiPier Mannuccio Mannucci
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
G LaffiP Gentilini
© 2021 Meta ULC. All rights reserved