Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site.

Cancer Research
Bin LiPampee P Young

Abstract

Microenvironmental cues instruct infiltrating tumor-associated myeloid cells to drive malignant progression. A subpopulation of tumor-associated myeloid cells coexpressing endothelial and myeloid markers, although rare in peripheral blood, are primarily associated with tumors where they enhance tumor growth and angiogenesis. These biphenotypic vascular leukocytes result from the endothelial differentiation of myeloid progenitors, a process regulated by tumor necrosis factor (TNF)alpha in vitro. An in vivo increase in tumor-derived TNFalpha expression promoted tumor growth and vascularity of mouse melanoma, lung cancer, and mammary tumors. Notably, tumor growth was accompanied by a significant increase in myeloid/endothelial biphenotypic populations. TNFalpha-associated tumor growth, vascularity, and generation of tumor vascular leukocytes in mouse melanoma tumors were dependent on intact host TNFalpha receptors. Importantly, TNFalpha-expressing tumors did not exhibit increased inflammation over control tumors, suggesting a unique action related to myeloid to endothelial differentiation. Our studies suggest that TNFalpha constitutes a tumor microenvironment signal that biases recruited monocytes toward a proangiogenic/provasculo...Continue Reading

References

Feb 1, 1988·The Journal of Clinical Investigation·D R SpriggsD W Kufe
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·C KalkaT Asahara
Aug 22, 2001·Trends in Cell Biology·V Baud, M Karin
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A WilluweitM Clauss
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 29, 2003·International Immunology·Tatjana NikolicPieter J M Leenen
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Sep 11, 2004·Blood·Jose R Conejo-GarciaGeorge Coukos
Mar 16, 2005·Cancer Cell·Frances BalkwillAlberto Mantovani
May 17, 2005·Journal of Leukocyte Biology·L S BarcelosM M Teixeira
Oct 19, 2005·Cancer Research·Mario P Colombo, Alberto Mantovani
Nov 18, 2005·Journal of Neuroimmunology·Masanori HangaiDavid R Hinton
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Jan 28, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Tang ZhuSylvain Chemtob
Mar 7, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter SzlosarekFrances R Balkwill
May 3, 2006·The American Journal of Pathology·Emerson E SharpePampee P Young
Aug 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alexis S BaileyWilliam H Fleming
Sep 26, 2006·Journal of Leukocyte Biology·Anita E M DirkxArjan W Griffioen
Oct 20, 2006·Cancer Letters·Michael C Schmid, Judith A Varner
Jan 31, 2007·Circulation·David A GoukassianDouglas W Losordo

❮ Previous
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Citations

Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Pampee P YoungBin Li
Apr 4, 2009·Nature Reviews. Cancer·Frances Balkwill
Dec 14, 2011·Oncogene·S P SasiD A Goukassian
Feb 23, 2012·Carcinogenesis·Yil Sik HyunHo-Youn Kim
Sep 11, 2009·The Journal of Clinical Investigation·Kellie A CharlesThorsten Hagemann
Mar 29, 2014·International Journal of Molecular Medicine·Guangwei ZhuYanling Chen
Jun 6, 2014·Journal of Immunology Research·Glauben LandskronMarcela A Hermoso
Jun 13, 2015·Critical Reviews in Food Science and Nutrition·C H LittleC S D Roxburgh
Mar 5, 2010·Clinical Pharmacology and Therapeutics·F Balkwill, A Mantovani
Jun 9, 2012·Gastroenterology·Marcelo B S FloresJosé B C Carvalheira
Jan 1, 2011·Cancers·Naofumi MukaidaBoryana K Popivanova
Jan 1, 2011·Cancers·Xuesong WuSam T Hwang
Sep 22, 2010·Journal of Cellular Physiology·Chun-Han HouChih-Hsin Tang
Oct 3, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui Xuan LimTae Sung Kim
Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Swati S Jain, Ranjana P Bird
Apr 1, 2010·International Journal of Experimental Pathology·Justin M M CatesPampee P Young
Sep 26, 2013·Nature Reviews. Cancer·James E Talmadge, Dmitry I Gabrilovich
May 19, 2012·Diseases of the Colon and Rectum·Matthew F KaladyJames M Church
Dec 24, 2019·The Journal of Dermatological Treatment·Ercan CalıskanMustafa Tunca
Mar 6, 2013·The Journal of Pathology·John P WatersJohn R Bradley
Aug 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei WangXianjun Fang
Sep 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seth G ThackerMariana J Kaplan
Nov 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao YinYuquan Wei
Mar 30, 2018·Frontiers in Immunology·Benoît L SalomonJosé L Cohen
Aug 17, 2019·Frontiers in Immunology·Anne MontfortBruno Ségui
Aug 31, 2010·Journal of Cellular Physiology·Gangaraju RajashekharMatthias Clauss
Apr 27, 2019·International Journal of Molecular Sciences·Matthew J BottomleyIrene Leigh
Apr 12, 2011·Cancer Research·Joshua L HoodSamuel A Wickline
Nov 17, 2020·SAGE Open Medicine·Mohammad Nurul AminFarhana Sultana
Mar 10, 2021·Nature Reviews. Rheumatology·Allen Y ChenAnne R Bass

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