Low levels of vitamin D are associated with multimorbidity: results from the LifeLines Cohort Study

Annals of Medicine
Laura M G MeemsRudolf A de Boer

Abstract

The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body. We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity. Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001). Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01). Low levels of vitamin D are associated with higher ...Continue Reading

References

Jul 5, 2001·Journal of Clinical Epidemiology·R GijsenG A van den Bos
Nov 7, 2002·Archives of Internal Medicine·Jennifer L WolffGerard Anderson
May 3, 2003·Journal of Clinical Epidemiology·Vincent de GrootLex M Bouter
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Dec 14, 2007·European Journal of Epidemiology·Ronald P StolkBruce H R Wolffenbuttel
Aug 28, 2010·Current Drug Targets·Laura M G MeemsR A de Boer
Nov 26, 2010·Archives of Internal Medicine·An PanFrank B Hu
Nov 30, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudia DiederichsDorothee B Bartels
Apr 17, 2012·Archives of Biochemistry and Biophysics·Yongji WangHector F DeLuca
Jun 15, 2012·Food & Function·Meinrad Peterlik
Oct 26, 2012·Anti-cancer Agents in Medicinal Chemistry·Edward Giovannucci
Apr 23, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·L G González-RodríguezUNKNOWN UCM Research Group VALORNUT (920030)
Apr 26, 2013·The American Journal of Clinical Nutrition·Michael C SachsIan H de Boer
Jun 25, 2013·Mayo Clinic Proceedings·Arash Hossein-nezhad, Michael F Holick
Aug 13, 2013·The British Journal of Nutrition·Jennifer HilgerKristina Hoffmann
Nov 23, 2013·Clinical Epidemiology·Henrik Toft Sørensen
Dec 12, 2013·BMC Public Health·Calypse B AgborsangayaJeffrey A Johnson
Jan 22, 2014·Journal of Internal Medicine·C AnnweilerO Beauchet
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Philippe AutierPatrick Mullie
Jun 19, 2014·BMJ : British Medical Journal·Ben SchöttkerUNKNOWN Consortium on Health and Ageing: Network of Cohorts in Europe and the United States
Jun 21, 2014·International Journal of Environmental Research and Public Health·Daniele MandiaRoberto Bergamaschi
Jul 18, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Idris GuessousUNKNOWN Swiss Survey on Salt Group
Jul 23, 2014·Expert Review of Gastroenterology & Hepatology·Simon Ghaly, Ian Lawrance
Aug 22, 2014·The European Respiratory Journal·Miguel J DivoDavid M Mannino

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Citations

Oct 6, 2016·Iranian Journal of Cancer Prevention·Reza Shekarriz-Foumani, Faezeh Khodaie
Apr 13, 2017·European Journal of Human Genetics : EJHG·Ilja M NolteHarold Snieder
Jul 28, 2017·European Journal of Nutrition·Szabolcs PéterManfred Eggersdorfer
May 5, 2018·Heart and Vessels·Ilona Korzonek-SzlachetaBarbara Zubelewicz-Szkodzinska
Jan 8, 2021·Expert Review of Neurotherapeutics·Francesco PanzaMadia Lozupone
Jan 25, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Carlijn A WagenaarGerjan J Navis
Nov 27, 2020·Frontiers in Psychiatry·Madia LozuponeFrancesco Panza
Feb 10, 2021·International Journal of Geriatric Psychiatry·Karen S van den BergRadboud M Marijnissen
Apr 3, 2021·Journal of the American Medical Directors Association·Christian RauschUte Bültmann

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