Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle

Journal of Cachexia, Sarcopenia and Muscle
Daniel R MooreAdam P Johnston

Abstract

Age-related sarcopenia is accelerated by physical inactivity. Low-load resistance exercise (LLRE) counters inactivity-induced muscle atrophy in older adults, but changes in muscle fibre morphology are unstudied. We aimed to determine the impact of LLRE during short-term inactivity (step-reduction) on muscle fibre size and capillarity as well as satellite cell (SC) content in older skeletal muscle. Fourteen older (~71 years) male adults underwent 14 days of step reduction (<1500 steps/day) while performing six sessions of LLRE (~30% maximal strength) with one leg (SR + EX) while the contralateral leg served as an untrained control (SR). Seven healthy ambulatory age-matched male adults (~69 years) served as a comparator group (COM). Muscle biopsies were taken from the vastus lateralis after 14 days, and immunohistochemical analysis was performed to determine muscle fibre cross-sectional area (CSA), myonuclear content, SC content (PAX7+ cells), and total (C:F) and fibre type-specific (C:Fi) capillary-to-fibre ratios. Type I and II fibre CSA was greater in SR + EX compared with SR. Whereas there were no differences across fibre types between SR + EX and CON, type II fibre CSA was significantly lower in SR compared with COM. Type II...Continue Reading

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Citations

Jan 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Shuang RongWei Yang
Dec 6, 2019·Therapeutic Advances in Endocrinology and Metabolism·Kelly A Bowden DaviesDaniel J Cuthbertson
Jun 11, 2019·Frontiers in Nutrition·Sara Y OikawaStuart M Phillips
Sep 12, 2020·International Journal of Molecular Sciences·Alessia LenaJochen Springer
Mar 7, 2020·Journal of Applied Physiology·Tatiana MoroChristopher S Fry
Mar 17, 2020·Acta Physiologica·Tim SnijdersLex B Verdijk
Jul 3, 2019·Frontiers in Nutrition·Joseph W BealsStephan van Vliet
Oct 24, 2020·Australasian Journal on Ageing·Ben KirkGustavo Duque
Dec 8, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Philipe de Souto BarretoYves Rolland
Jul 21, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marcelo A S CarneiroFábio L Orsatti

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Methods Mentioned

BETA
biopsies

Software Mentioned

FIJI
GraphPad Prism
GraphPad

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