Low malignant potential tumors with micropapillary features are molecularly similar to low-grade serous carcinoma of the ovary

Gynecologic Oncology
Taymaa MayPatricia A Shaw

Abstract

Low-grade serous carcinoma (LGSC) is a chemoresistant ovarian neoplasm thought to potentially arise in a background of low malignant potential tumors (LMP), which are typically non-aggressive. However, LMP with micropapillary features (LMP-MP) have more aggressive clinical behavior and may represent an intermediate in progression to LGSC. The objective of this study was to obtain and compare gene expression profiles of LMP, LMP-MP and LGSC to determine if LMP-MP more closely resembles LGSC, and to identify genes involved in LGSC carcinogenesis. Epithelial cells from LMP (n=17), LMP-MP (n=9) and LGSC (n=11) were isolated by laser capture microdissection. RNA was extracted, reverse transcribed to cDNA, amplified and hybridized to Affymetrix U133 Plus2 genechip arrays. Gene expression data were checked for quality, filtered and significantly altered genes between subgroups were identified. Differential expression of selected genes was verified by RT-qPCR and immunohistochemistry. Gene expression analysis identified differential expression between LMP and LMP-MP, LMP and LGSC but not LMP-MP and LGSC. Integration of differentially expressed genes into the protein interaction database CytoScape highlighted gene products in the MAPK p...Continue Reading

References

Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R BarnhillL D Roman
Feb 15, 2001·Current Opinion in Obstetrics & Gynecology·W B Chapman
Sep 26, 2001·Lancet·A N Gjorgov
Sep 26, 2001·Lancet·J M PiekR H Verheijen
Apr 12, 2002·The American Journal of Pathology·Gad SingerIe-Ming Shih
Jul 30, 2002·Gynecologic Oncology·Robert E BristowF J Montz
Sep 5, 2002·Cancer·Robert E BristowFredrick J Montz
Feb 13, 2003·Nucleic Acids Research·Rafael A IrizarryTerence P Speed
Mar 20, 2003·Journal of the National Cancer Institute·Gad SingerIe-Ming Shih
Jan 23, 2004·Oncogene·Xiaoqi LiuRaymond L Erikson
Feb 7, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A P HeintzS Pecorelli
Feb 28, 2004·Expert Reviews in Molecular Medicine·Walter KolchPetra Janosch
Apr 17, 2004·The American Journal of Surgical Pathology·Anais MalpicaElvio G Silva
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William R Hart
Apr 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tiina M KauppinenRaymond A Swanson
Nov 14, 2006·Bioinformatics·S Falcon, R Gentleman
Dec 6, 2006·Nucleic Acids Research·S KerrienH Hermjakob
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Christopher P CrumYonghee Lee
Aug 19, 2007·Nucleic Acids Research·Stefano CalzaYudi Pawitan
Dec 19, 2007·Nucleic Acids Research·D KarolchikW J Kent
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alicia A TonePatricia A Shaw
Oct 10, 2008·Annual Review of Pathology·Kathleen R Cho, Ie-Ming Shih
Mar 18, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Maryla KrajewskaStan Krajewski
Apr 14, 2009·Gynecologic Oncology·David M GershensonJohn J Kavanagh
Jun 23, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Patricia A ShawHeather Begley
Oct 2, 2009·Lancet·Bryan T HennessyMaurie Markman
Aug 14, 2013·Annual Review of Pathology·Niloofar N NikRobert J Kurman

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Citations

Jan 18, 2014·Gynecologic Oncology·Caela R MillerJohn H Farley
Aug 3, 2013·Briefings in Bioinformatics·Irene KouskoumvekakiSøren Brunak
Aug 21, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Edward W J CurryMona A El-Bahrawy
Oct 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R FauvetE Daraï
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W WeiM J Birrer
Oct 30, 2012·Gynecologic Oncology·Jorge EscobarMartin Köbel
Sep 16, 2011·Gynecologic Oncology·Jeong-Yeol ParkJoo-Hyun Nam
Jul 12, 2011·The Journal of Pathology·Sophia Hl GeorgePatricia A Shaw
Nov 22, 2011·The Journal of Pathology·Siân JonesIe-Ming Shih
Oct 24, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Francisco Sánchez-VegaLaura Elnitski
May 28, 2013·Gynecologic Oncology·Ignacio RomeroDavid M Gershenson
May 4, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J KrzystyniakM J Birrer
Sep 13, 2015·Journal of Clinical Pathology·Ahmed El-BalatKnut Engels
Aug 8, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zibi MarchockiTaymaa May
Dec 28, 2016·Virchows Archiv : an International Journal of Pathology·Steffen HauptmannStefanie Avril
Sep 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sophia H L GeorgePatricia A Shaw

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