Low metacarpal index predicts hip fracture: a prospective population study of 3,561 subjects with 15 years of follow-up

Acta Orthopaedica
Mikko HaaraHeikki Kröger

Abstract

Metacarpal index (MCI), measured from hand radiographs as the ratio between combined cortical thickness and bone diameter, has been suggested for assessment of bone mass and risk of osteoporotic fracture. We studied MCI for its ability to predict hip fractures. Hand radiographs were taken and MCI determined in 3,561 subjects from a representative population sample of 8,000 Finns who were 30 years of age or over in 1978-80. Record linkage to the National Hospital Discharge Register identified 117 subjects who had been hospitalized for primary treatment of hip fracture by the end of 1994. High age, low body mass index, tall stature and smoking at baseline showed, independently of each other, significant associations with low MCI. Low MCI was a strong predictor of hip fracture. When adjusted for all potential confounding factors, the relative risk of hip fracture per decrement of MCI by one standard deviation (0.1) was 1.5 (95% CI 1.2-1.8). Low MCI is associated with known risk factors of osteoporosis and predicts hip fracture. Since hand radiographs are easily available at low cost, measurements of MCI can be used as an alternative approach to find osteoporotic individuals with a high risk of hip fracture.

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Citations

Mar 15, 2006·Acta Orthopaedica·Olle Svensson
Feb 3, 2007·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·A SchmittE Cunha
Oct 19, 2017·International Journal of Epidemiology·Paul KnektMarkku Heliövaara
Dec 30, 2015·Journal of Bone Metabolism·Je-Hyun YooKyu Hyun Yang
Apr 23, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Leonid KalichmanGregory Livshits
Sep 1, 2018·Calcified Tissue International·A MaganJ M Pettifor
Apr 1, 2017·JDR Clinical and Translational Research·E K KayeR I Garcia
Feb 19, 2021·Journal of Biomechanics·Eduardo M Sosa, Faisal M Alessa

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