Low micromolar concentrations of copper augment the impairment of endothelium-dependent relaxation of aortae from diabetic rabbits

Metabolism: Clinical and Experimental
N ShuklaJ Y Jeremy

Abstract

Both diabetes mellitus (DM) and elevated plasma copper concentrations are risk factors for cardiovascular disease (CVD). DM is associated with impaired endothelial nitric oxide (NO) and with excess superoxide (O2*-) formation. Copper is also elevated in DM and is also associated with the generation of O2*-. To explore possible interactions between DM and copper, the effect of exogenous copper (CuCl2) on endothelium-dependent relaxation and cyclic guanosine monophosphate (GMP) formation was investigated in aortae from diabetic rabbits. Rabbits were rendered diabetic by intravenous injection of alloxan. Six months after induction of DM, the aortae were excised, cut into rings, and mounted in an organ bath for isometric measurement of acetylcholine (Ach)-evoked relaxation in rings precontracted with phenylephrine (PE). In parallel studies, cyclic (c)GMP formation by aortic rings following stimulation with Ach, calcium ionophore A23187 (A23187) and sodium nitroprusside (SNP) was assessed using radioimmunoassay. The effect of copper on these parameters was then studied using the same methods. Ach-evoked relaxation and Ach- and A23187-evoked cGMP formation were significantly impaired in aortae from diabetic rabbits compared to contro...Continue Reading

References

Apr 1, 1986·The Journal of Clinical Investigation·G Starkebaum, J M Harlan
Oct 1, 1996·British Journal of Pharmacology·K Kamata, T Kobayashi
Mar 2, 1999·Archives of Biochemistry and Biophysics·J P FabisiakV E Kagan
Apr 10, 1999·Postgraduate Medical Journal·A H ZargarA I Wani
Dec 22, 1999·Neurology·J W Schmidley
Feb 24, 2000·The Journal of Pathology·H Li, U Förstermann
Feb 7, 2001·Diabetologia·N N ChanH M Colhoun
May 29, 2000·Free Radical Research·R H KimJ W Park
Aug 18, 2000·Free Radical Biology & Medicine·P L FoxC K Mukhopadhyay
Aug 30, 2000·Cardiovascular Research·R F AmmarK C Dellsperger
Jun 16, 2001·British Journal of Pharmacology·S F O'BrienJ C Russell
May 15, 2002·European Journal of Pharmacology·Tsuneo Kobayashi, Katsuo Kamata
May 22, 2002·JAMA : the Journal of the American Medical Association·Joshua A BeckmanPeter Libby
Aug 7, 2002·British Journal of Pharmacology·Alberto ChiarugiSalvatore Salomone
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim Tapiero, Kenneth D Tew

❮ Previous
Next ❯

Citations

Oct 21, 2006·International Journal of Impotence Research·J Y JeremyN Shukla
May 27, 2008·Metabolism: Clinical and Experimental·Nilima ShuklaJamie Y Jeremy
Nov 6, 2007·Journal of Ethnopharmacology·Goksel Gokce, Mehmet Zeki Haznedaroglu
Jun 26, 2007·The Annals of Thoracic Surgery·Nilima ShuklaJamie Y Jeremy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.