PMID: 11336232May 5, 2001Paper

Low microsatellite variation in laboratory gerbrils

The Journal of Heredity
K NeumannR Gattermann

Abstract

The Mongolian gerbil has become a model organism of increasing importance for the understanding of aging, epilepsy, the process of domestication or sociobiological questions. We report the development and characterization of the first nine polymorphic dinucleotide repeat loci in this species. Average observed heterozygosity and allele number of laboratory animals measured 0.136 (SE = +/-0.065) and 1.78 (SE = +/-0.278) compared to 0.761 (SE = +/-0.025) and 9.2 (SE = +/-0.57) found for a reference group of wild gerbils. The extreme low genetic variation observed in laboratory animals is caused by several severe population size bottlenecks due to the initial founder event and the later establishment of subpopulations. Reduced levels of allelic polymorphism in experimental animals hamper genetic mapping or parental studies. Therefore experiments relying on kinship analyses have to be carried out on wild animals. Estimates of genetic identity and parental exclusion were calculated as Pid = 2.8 x 10(-12) and Pex > 0.999 in wild gerbils. Laboratory gerbil strains show the expected high degree of genetic similarity. However, significant allele frequency differences (P < .001) between American and European gerbils at some microsatellite...Continue Reading

Citations

Sep 1, 2005·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·R PapaF Nonnis Marzano
Nov 2, 2011·Experimental Animals·Xiao-Hui Lv, Da-Zhao Shi
Jul 23, 2011·The Journal of Heredity·Yanni WangXinrong Wan
Sep 10, 2008·Yi chuan = Hereditas·Xian-Ming DingZhang-Kui Shi
Apr 28, 2012·American Journal of Primatology·Aixue LiYansheng Shi
Dec 16, 2017·G3 : Genes - Genomes - Genetics·Thomas D BrekkeJohn F Mulley

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