Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology.

Frontiers in Oncology
Piero Di BattistaLara Mussolin

Abstract

The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.

References

May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Charles H LawrieChristian S R Hatton
Jan 11, 2008·Leukemia·C H LawrieC S R Hatton
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Olaf MerkelLukas Kenner
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Willi WoessmannAlfred Reiter
Feb 26, 2016·British Journal of Haematology·Suzanne D TurnerLaurence Brugières
Feb 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sankhiros BabapoorSoheil S Dadras
Nov 5, 2017·Oncotarget·Dana JurkovicovaIvana Fridrichova
Sep 21, 2018·Journal of Hematology & Oncology·Marcia BellonChristophe Nicot
Jun 20, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhichao YaoHe Huang
Jan 21, 2020·European Review for Medical and Pharmacological Sciences·H-F LiuY-K Fan
Mar 8, 2020·International Journal of Molecular Sciences·Enrico GaffoStefania Bortoluzzi
Sep 30, 2020·Cancers·Lara MussolinMarta Pillon On Behalf Of The European Inter-Group For Childhood Non-Hodgkin Lymphoma Pillon

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Software Mentioned

DESeq2
moRe2
miR

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