Low miR200b-5p levels in minor salivary glands: a novel molecular marker predicting lymphoma development in patients with Sjögren's syndrome

Annals of the Rheumatic Diseases
E K KapsogeorgouAthanasios G Tzioufas

Abstract

Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS patients with NHL. The aim of the current study was to evaluate the MSG expression of miR200b-5p in SS-associated NHLs and its potential predictive value for the identification of patients with SS susceptible to develop NHL. miR200b-5p expression was investigated in MSG tissues of patients with SS who were at: (A) low risk and did not develop NHL during follow-up (n=27; median follow-up time on biopsy performance, range: 8.9 years, 1.33-14 years), (B) high-risk and diagnosed with NHL during follow-up (prelymphoma; n=17; median follow-up to until lymphoma diagnosis, range: 3.67 years, 0.42-8.5 years) and (C) had NHL (n=35), as well as non-SS sialadenitis controls (sarcoidosis and hepatitis C virus (HCV) infection, four each). The differential miR200b-5p expression, correlations with disease features and its discriminative/predictive value, was evaluated by appropriate statistical approaches. The MSG levels of miR200b-5p were sig...Continue Reading

Citations

Jul 22, 2018·Annals of the Rheumatic Diseases·Gaetane NocturneXavier Mariette
Nov 7, 2019·International Journal of Molecular Sciences·Chiara RizzoGiuliana Guggino
Dec 2, 2020·Journal of Clinical Medicine·Ioanna E StergiouMichael Voulgarelis
Apr 4, 2021·Biomedicines·Pinelopi I ArtemakiChristos K Kontos
Jun 25, 2021·Frontiers in Medicine·Claudio VitaliNicoletta Del Papa
Jul 3, 2021·Genes·Giada De BenedittisPaola Borgiani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.